{"ticker": {"uuid": "67d00e45-75b2-4ca0-8350-44ee3d6fc7d0", "symbol": "DNLI", "name": "Denali Therapeutics Inc", "sector": "Healthcare", "industry": "Biotechnology", "currency": "USD"}, "next_event": {"report_date": "2026-11-05", "fiscal_date_ending": "2026-09-30", "estimate": -0.67, "session": "Time unconfirmed", "days": 23}, "profile": {"sample": 12, "measured": 12, "beats": 8, "misses": 3, "inline": 1, "beat_rate": 66.7, "beat_rate_label": "66.7%", "average_surprise": 2.0, "average_surprise_label": "+2.0%", "median_surprise": 2.7, "surprise_dispersion": 10.2, "average_reaction": -0.3, "average_reaction_label": "-0.3%", "average_abs_reaction": 12.2, "positive_response_rate": 58.3, "confirmation_rate": 45.5, "reaction_sample": 12, "streak": {"count": 5, "band": "beat", "label": "5 consecutive beats"}, "profile": "Mixed earnings transmission", "profile_tone": "neutral", "profile_text": "Delivery and market response do not currently form a persistent directional pattern."}, "event_risk": {"score": 62, "band": "Elevated", "tone": "caution", "days": 23, "proximity_component": 14, "reaction_component": 30, "variability_component": 13, "uncertainty_component": 5, "explanation": "Event risk combines report proximity, historical price movement, surprise variability, estimate availability and confirmed timing. It measures uncertainty, not direction."}, "evidence": {"score": 95, "band": "Deep", "exact": 12, "surprise": 12, "reaction": 12, "financial": 6, "total": 12}, "factor_context": {"available": true, "as_of": "2026-10-09", "eps_growth_1y": null, "revenue_growth_1y": null, "cash_conversion": 0.86, "net_margin": -14191.2, "earnings_yield": null, "eps_surprise_avg": 3.4, "sue_score": 0.37, "pe_ratio": null, "completeness": 71.4, "source": "alphavantage"}, "market_context": {"available": true, "as_of": "2026-10-09", "close": 19.45, "currency": "USD", "return_13w": -24.3, "fair_value": 19.638718, "fair_value_gap": -1.0, "relative_strength": -15.6, "trend_signal": "Inactive", "expectation_direction": "undecided", "expectation_probability": 45.6}, "records": [{"period_end": "2023-09-30", "reported_date": "2023-11-07", "date_source": "exact", "eps_actual": -0.72, "eps_estimate": -0.79, "eps_surprise": 0.07, "surprise_pct": 8.8608, "surprise_label": "+8.9%", "surprise_band": "beat", "eps_yoy": null, "eps_yoy_label": "-", "one_week_reaction": -25.69857993586807, "one_week_reaction_label": "-25.7%", "four_week_reaction": -13.10123683005039, "four_week_reaction_label": "-13.1%", "confirmation": "diverged", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2023-12-31", "reported_date": "2024-02-27", "date_source": "exact", "eps_actual": -0.86, "eps_estimate": -0.8, "eps_surprise": -0.06, "surprise_pct": -7.5, "surprise_label": "-7.5%", "surprise_band": "miss", "eps_yoy": null, "eps_yoy_label": "-", "one_week_reaction": 23.2132309509746, "one_week_reaction_label": "+23.2%", "four_week_reaction": 15.888954518606033, "four_week_reaction_label": "+15.9%", "confirmation": "diverged", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2024-03-31", "reported_date": "2024-05-07", "date_source": "exact", "eps_actual": -0.78, "eps_estimate": -0.66, "eps_surprise": -0.12, "surprise_pct": -18.1818, "surprise_label": "-18.2%", "surprise_band": "miss", "eps_yoy": null, "eps_yoy_label": "-", "one_week_reaction": 6.826137689614925, "one_week_reaction_label": "+6.8%", "four_week_reaction": 8.284714119019826, "four_week_reaction_label": "+8.3%", "confirmation": "diverged", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2024-06-30", "reported_date": "2024-08-01", "date_source": "exact", "eps_actual": -0.59, "eps_estimate": -0.69, "eps_surprise": 0.1, "surprise_pct": 14.4928, "surprise_label": "+14.5%", "surprise_band": "beat", "eps_yoy": null, "eps_yoy_label": "-", "one_week_reaction": -9.253112033195023, "one_week_reaction_label": "-9.3%", "four_week_reaction": 2.7800829875518596, "four_week_reaction_label": "+2.8%", "confirmation": "diverged", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2024-09-30", "reported_date": "2024-11-06", "date_source": "exact", "eps_actual": -0.63, "eps_estimate": -0.63, "eps_surprise": 0.0, "surprise_pct": 0.0, "surprise_label": "0.0%", "surprise_band": "in-line", "eps_yoy": 12.499999999999996, "eps_yoy_label": "+12.5%", "one_week_reaction": 15.89648798521257, "one_week_reaction_label": "+15.9%", "four_week_reaction": -7.578558225508321, "four_week_reaction_label": "-7.6%", "confirmation": "contained", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2024-12-31", "reported_date": "2025-02-27", "date_source": "exact", "eps_actual": -0.67, "eps_estimate": -0.8459, "eps_surprise": 0.1759, "surprise_pct": 20.7944, "surprise_label": "+20.8%", "surprise_band": "beat", "eps_yoy": 22.093023255813947, "eps_yoy_label": "+22.1%", "one_week_reaction": -20.115774240231556, "one_week_reaction_label": "-20.1%", "four_week_reaction": -30.39073806078148, "four_week_reaction_label": "-30.4%", "confirmation": "diverged", "revenue": null, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": null, "operating_cash_flow": null, "free_cash_flow": null, "currency": "USD"}, {"period_end": "2025-03-31", "reported_date": "2025-05-06", "date_source": "exact", "eps_actual": -0.78, "eps_estimate": -0.7, "eps_surprise": -0.08, "surprise_pct": -11.4286, "surprise_label": "-11.4%", "surprise_band": "miss", "eps_yoy": 0.0, "eps_yoy_label": "0.0%", "one_week_reaction": -12.59124087591242, "one_week_reaction_label": "-12.6%", "four_week_reaction": -19.464720194647207, "four_week_reaction_label": "-19.5%", "confirmation": "confirmed", "revenue": 0.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -132970000.0, "operating_cash_flow": -131468000.0, "free_cash_flow": -136546000.0, "currency": "USD"}, {"period_end": "2025-06-30", "reported_date": "2025-08-11", "date_source": "exact", "eps_actual": -0.72, "eps_estimate": -0.74, "eps_surprise": 0.02, "surprise_pct": 2.7027, "surprise_label": "+2.7%", "surprise_band": "beat", "eps_yoy": -22.033898305084747, "eps_yoy_label": "-22.0%", "one_week_reaction": 5.300859598853857, "one_week_reaction_label": "+5.3%", "four_week_reaction": 10.530085959885378, "four_week_reaction_label": "+10.5%", "confirmation": "confirmed", "revenue": 0.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -124119000.0, "operating_cash_flow": -75298000.0, "free_cash_flow": -79576000.0, "currency": "USD"}, {"period_end": "2025-09-30", "reported_date": "2025-11-06", "date_source": "exact", "eps_actual": -0.74, "eps_estimate": -0.76, "eps_surprise": 0.02, "surprise_pct": 2.6316, "surprise_label": "+2.6%", "surprise_band": "beat", "eps_yoy": -17.46031746031746, "eps_yoy_label": "-17.5%", "one_week_reaction": -7.739557739557748, "one_week_reaction_label": "-7.7%", "four_week_reaction": 19.59459459459458, "four_week_reaction_label": "+19.6%", "confirmation": "diverged", "revenue": 0.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -126902000.0, "operating_cash_flow": -107296000.0, "free_cash_flow": -108674000.0, "currency": "USD"}, {"period_end": "2025-12-31", "reported_date": "2026-02-26", "date_source": "exact", "eps_actual": -0.73, "eps_estimate": -0.75, "eps_surprise": 0.02, "surprise_pct": 2.6667, "surprise_label": "+2.7%", "surprise_band": "beat", "eps_yoy": -8.955223880597005, "eps_yoy_label": "-9.0%", "one_week_reaction": 4.903417533432384, "one_week_reaction_label": "+4.9%", "four_week_reaction": -0.09905894006933914, "four_week_reaction_label": "-0.1%", "confirmation": "confirmed", "revenue": 0.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -128549000.0, "operating_cash_flow": -98538000.0, "free_cash_flow": -100062000.0, "currency": "USD"}, {"period_end": "2026-03-31", "reported_date": "2026-05-07", "date_source": "exact", "eps_actual": -0.69, "eps_estimate": -0.71, "eps_surprise": 0.02, "surprise_pct": 2.8169, "surprise_label": "+2.8%", "surprise_band": "beat", "eps_yoy": 11.538461538461549, "eps_yoy_label": "+11.5%", "one_week_reaction": 7.2131147540983624, "one_week_reaction_label": "+7.2%", "four_week_reaction": 14.972677595628406, "four_week_reaction_label": "+15.0%", "confirmation": "confirmed", "revenue": 0.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -128447000.0, "operating_cash_flow": -131204000.0, "free_cash_flow": -133670000.0, "currency": "USD"}, {"period_end": "2026-06-30", "reported_date": "2026-08-06", "date_source": "exact", "eps_actual": -0.68, "eps_estimate": -0.72, "eps_surprise": 0.04, "surprise_pct": 5.5556, "surprise_label": "+5.6%", "surprise_band": "beat", "eps_yoy": 5.555555555555546, "eps_yoy_label": "+5.6%", "one_week_reaction": 7.862728062554296, "one_week_reaction_label": "+7.9%", "four_week_reaction": 4.257167680278021, "four_week_reaction_label": "+4.3%", "confirmation": "confirmed", "revenue": 3604000.0, "revenue_yoy": null, "revenue_yoy_label": "-", "net_income": -127553000.0, "operating_cash_flow": -97002000.0, "free_cash_flow": -97807000.0, "currency": "USD"}], "charts": {"quarters": ["2023-09-30", "2023-12-31", "2024-03-31", "2024-06-30", "2024-09-30", "2024-12-31", "2025-03-31", "2025-06-30", "2025-09-30", "2025-12-31", "2026-03-31", "2026-06-30"], "eps_actual": [-0.72, -0.86, -0.78, -0.59, -0.63, -0.67, -0.78, -0.72, -0.74, -0.73, -0.69, -0.68], "eps_estimate": [-0.79, -0.8, -0.66, -0.69, -0.63, -0.8459, -0.7, -0.74, -0.76, -0.75, -0.71, -0.72], "surprise": [8.8608, -7.5, -18.1818, 14.4928, 0.0, 20.7944, -11.4286, 2.7027, 2.6316, 2.6667, 2.8169, 5.5556], "reaction_1w": [-25.69857993586807, 23.2132309509746, 6.826137689614925, -9.253112033195023, 15.89648798521257, -20.115774240231556, -12.59124087591242, 5.300859598853857, -7.739557739557748, 4.903417533432384, 7.2131147540983624, 7.862728062554296], "reaction_4w": [-13.10123683005039, 15.888954518606033, 8.284714119019826, 2.7800829875518596, -7.578558225508321, -30.39073806078148, -19.464720194647207, 10.530085959885378, 19.59459459459458, -0.09905894006933914, 14.972677595628406, 4.257167680278021], "revenue": [null, null, null, null, null, null, 0.0, 0.0, 0.0, 0.0, 0.0, 3.6], "net_income": [null, null, null, null, null, null, -132.97, -124.12, -126.9, -128.55, -128.45, -127.55], "financial_unit": "millions", "scatter": [{"x": 8.8608, "y": -25.69857993586807, "label": "2023-09-30"}, {"x": -7.5, "y": 23.2132309509746, "label": "2023-12-31"}, {"x": -18.1818, "y": 6.826137689614925, "label": "2024-03-31"}, {"x": 14.4928, "y": -9.253112033195023, "label": "2024-06-30"}, {"x": 0.0, "y": 15.89648798521257, "label": "2024-09-30"}, {"x": 20.7944, "y": -20.115774240231556, "label": "2024-12-31"}, {"x": -11.4286, "y": -12.59124087591242, "label": "2025-03-31"}, {"x": 2.7027, "y": 5.300859598853857, "label": "2025-06-30"}, {"x": 2.6316, "y": -7.739557739557748, "label": "2025-09-30"}, {"x": 2.6667, "y": 4.903417533432384, "label": "2025-12-31"}, {"x": 2.8169, "y": 7.2131147540983624, "label": "2026-03-31"}, {"x": 5.5556, "y": 7.862728062554296, "label": "2026-06-30"}], "earnings_price": {"available": false, "dates": [], "price_index": [], "eps_index": [], "gap": [], "quarter_markers": [], "bridge_labels": [], "bridge_values": []}}, "earnings_price": {"available": false, "reason": "Earnings power must be positive at the start of the three-year window."}, "disclaimer": "Earnings intelligence is descriptive market research. It is not a forecast, recommendation or trading instruction."}