{"ticker": {"uuid": "2343b247-36a5-4b4e-89e3-a59397cef98f", "symbol": "ORY", "name": "Oryzon Genomics S.A.", "exchange": "MCE", "asset_type": "equity"}, "latest_week": "2026-08-07", "summary": "ORY closed the latest completed week at 2.91 EUR. The 4-week return is 1.2% and the 12-week return is 3.4%. The trend backdrop is inactive, with activity pressure at 0.12.", "description": "Oryzon Genomics S.A., a clinical stage biopharmaceutical company, engages in the discovery and development of epigenetics-based therapeutics for patients with cancer and CNS (central nervous system), oncology, and hematology disorders. Its clinical phase compounds include iadademstat (ORY-1001), a selective LSD1 inhibitor that is in Phase II trials for oncology; and vafidemstat (ORY-2001), a CNS-optimized LSD1 inhibitor, which is in Phase II trials for the treatment of CNS and psychiatric diseases. Its product candidates also comprise ORY-3001, an LSD1 inhibitor that is in preclinical development for the treatment of non-oncological diseases; and ORY-4001, a selective HDAC-6 inhibitor for the treatment of neurological disorders, such as Charcot-Marie-Tooth disease (CMT), amyotrophic lateral sclerosis (ALS), and others. It also has collaborations in precision medicine with Columbia University in New York and the Institute of Medical and Molecular Genetics (INGEMM) at La Paz Hospital in Madrid psychometrically characterize patients with mutations in the SetD1A or Shank3 genes; and Cooperative Research and Development Agreement (CRADA) to sponsor several clinical trials. The company was incorporated in 2000 and is based in Cornell\u00e0 de Llobregat, Spain.", "setup_signature": "Risk-first tape", "composite_score": "34", "kpis": [{"label": "Latest Close", "value": "2.91 EUR", "hint": "2026-08-07"}, {"label": "1W Return", "value": "-0.1%", "tone": "negative", "hint": "latest completed week"}, {"label": "4W Return", "value": "1.2%", "tone": "positive", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "3.4%", "tone": "positive", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "46.2%", "hint": "24 of 52 weeks active"}, {"label": "Volume Ratio", "value": "0.8x", "hint": "vs 13-week average"}], "classification": {"exchange": "MCE", "country": "ES", "sector": "Healthcare", "industry": "Biotechnology", "currency": "EUR", "market_cap": "241.6M"}, "price": {"trend_line": "2.97 EUR", "fair_value": "2.39 EUR", "vs_trend": "-1.9%", "vs_fair_value": "21.8%", "high_52": "4.02 EUR", "low_52": "2.57 EUR", "drawdown": "-27.6%", 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"return_label": "-0.2%", "return_tone": "negative", "volume_height": 4.684450819821322, "volume": "190.5K"}, {"week": "26 Jun", "return": 1.403061224489797, "return_label": "1.4%", "return_tone": "positive", "volume_height": 12.311733300669365, "volume": "500.6K"}, {"week": "3 Jul", "return": -6.163522012578621, "return_label": "-6.2%", "return_tone": "negative", "volume_height": 16.757107487575148, "volume": "681.3K"}, {"week": "10 Jul", "return": -3.6193029490616655, "return_label": "-3.6%", "return_tone": "negative", "volume_height": 40.83829810888416, "volume": "1.7M"}, {"week": "17 Jul", "return": 0.9040333796940281, "return_label": "0.9%", "return_tone": "positive", "volume_height": 18.697907981076543, "volume": "760.2K"}, {"week": "24 Jul", "return": 1.9297036526533442, "return_label": "1.9%", "return_tone": "positive", "volume_height": 47.48566155111542, "volume": "1.9M"}, {"week": "31 Jul", "return": -1.555104800540915, "return_label": "-1.6%", "return_tone": "negative", "volume_height": 38.9613989623287, "volume": "1.6M"}, {"week": "7 Aug", "return": -0.06868131868131112, "return_label": "-0.1%", "return_tone": "negative", "volume_height": 25.731680261075617, "volume": "1.0M"}], "insights": [{"label": "Participation", "value": "0.8x", "detail": "Latest volume versus the 13-week average.", "tone": "neutral"}, {"label": "Baseline", "value": "1.3M", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "2.8M", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "3.8%", "volatility_52": "5.6%", "downside_weeks": 28, "upside_weeks": 23, "downside_breadth": "53.8%", "average_gain": "4.9%", "average_loss": "-3.4%", "distribution_scale": "12%", "return_callouts": [{"label": "Weeks higher", "value": "12 of 26", "detail": "13 weeks finished lower.", "tone": "negative"}, {"label": "Best week", "value": "+7.6%", "detail": "Week of 22 May.", "tone": "positive"}, {"label": "Worst week", "value": "-11.8%", "detail": "Week of 6 Mar.", "tone": "negative"}, {"label": "Latest week", "value": "-0.1%", "detail": "Week of 7 Aug.", "tone": "negative"}], "buckets": [{"label": "Strong gains", "count": 3, "share": 11.538461538461538, "share_label": "11.5%", "tone": "positive"}, {"label": "Modest gains", "count": 9, "share": 34.61538461538461, "share_label": "34.6%", "tone": "positive"}, {"label": "Flat weeks", "count": 1, "share": 3.8461538461538463, "share_label": "3.8%", "tone": "neutral"}, {"label": "Modest losses", "count": 10, "share": 38.46153846153847, "share_label": "38.5%", "tone": "negative"}, {"label": "Sharp losses", "count": 3, "share": 11.538461538461538, "share_label": "11.5%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "3.8%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "5.6%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "23/28", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "negative"}, {"label": "Average skew", "value": "4.9% / -3.4%", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Inactive", "tone": "negative"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "-1.9%", "tone": "negative"}, {"label": "Volume", "value": "0.8x", "tone": "neutral"}], "opportunities": ["Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is positive on the latest completed week."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below the Trend Line, which keeps downside pressure in focus.", "Activity pressure is weak, so confirmation is not yet broad enough.", "The share remains more than 20% below its 52-week high."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-08-07", "close": "2.91 EUR", "return": null, "return_tone": null, "trend_line": "2.97 EUR", "fair_value": "2.39 EUR", "activity_pressure": "0.12", "relative_leadership": "-18.06", "volume": "1.0M", "trend_backdrop": null}, {"week": "2026-07-31", "close": "2.91 EUR", "return": null, "return_tone": null, "trend_line": "2.98 EUR", "fair_value": "2.38 EUR", "activity_pressure": "0.22", "relative_leadership": "-16.68", "volume": "1.6M", "trend_backdrop": null}, {"week": "2026-07-24", "close": "2.96 EUR", "return": null, "return_tone": null, "trend_line": "2.99 EUR", "fair_value": "2.38 EUR", "activity_pressure": "0.28", "relative_leadership": "-14.86", "volume": "1.9M", "trend_backdrop": null}, {"week": "2026-07-17", "close": "2.90 EUR", "return": null, "return_tone": null, "trend_line": "2.99 EUR", "fair_value": "2.37 EUR", "activity_pressure": "0.35", "relative_leadership": "-15.26", "volume": "760.2K", "trend_backdrop": null}, {"week": "2026-07-10", "close": "2.88 EUR", "return": null, "return_tone": null, "trend_line": "3.00 EUR", "fair_value": "2.37 EUR", "activity_pressure": "0.51", "relative_leadership": "-17.22", "volume": "1.7M", "trend_backdrop": null}, {"week": "2026-07-03", "close": "2.98 EUR", "return": null, "return_tone": null, "trend_line": "3.01 EUR", "fair_value": "2.36 EUR", "activity_pressure": "0.62", "relative_leadership": "-16.61", "volume": "681.3K", "trend_backdrop": null}, {"week": "2026-06-26", "close": "3.18 EUR", "return": null, "return_tone": null, "trend_line": "3.01 EUR", "fair_value": "2.36 EUR", "activity_pressure": "0.60", "relative_leadership": "-9.58", "volume": "500.6K", "trend_backdrop": null}, {"week": "2026-06-19", "close": "3.14 EUR", "return": null, "return_tone": null, "trend_line": "3.02 EUR", "fair_value": "2.35 EUR", "activity_pressure": "0.70", "relative_leadership": "-10.74", "volume": "190.5K", "trend_backdrop": null}, {"week": "2026-06-12", "close": "3.14 EUR", "return": null, "return_tone": null, "trend_line": "3.01 EUR", "fair_value": "2.34 EUR", "activity_pressure": "0.72", "relative_leadership": "-8.13", "volume": "1.1M", "trend_backdrop": null}, {"week": "2026-06-05", "close": "2.99 EUR", "return": null, "return_tone": null, "trend_line": "3.01 EUR", "fair_value": "2.34 EUR", "activity_pressure": "0.32", "relative_leadership": "-10.76", "volume": "386.5K", "trend_backdrop": null}, {"week": "2026-05-29", "close": "3.14 EUR", "return": null, "return_tone": null, "trend_line": "3.02 EUR", "fair_value": "2.33 EUR", "activity_pressure": "-0.10", "relative_leadership": "-6.74", "volume": "3.0M", "trend_backdrop": null}, {"week": "2026-05-22", "close": "3.03 EUR", "return": null, "return_tone": null, "trend_line": "3.03 EUR", "fair_value": "2.33 EUR", "activity_pressure": "-0.73", "relative_leadership": "-8.48", "volume": "3.1M", "trend_backdrop": null}, {"week": "2026-05-15", "close": "2.81 EUR", "return": null, "return_tone": null, "trend_line": "3.04 EUR", "fair_value": "2.32 EUR", "activity_pressure": "-1.23", "relative_leadership": "-13.39", "volume": "1.1M", "trend_backdrop": null}, {"week": "2026-05-08", "close": "2.73 EUR", "return": null, "return_tone": null, "trend_line": "3.06 EUR", "fair_value": "2.31 EUR", "activity_pressure": "-1.28", "relative_leadership": "-17.60", "volume": "1.2M", "trend_backdrop": null}], "intelligence": {"rating": "Caution", "rating_tone": "negative", "overall_score": "37", "primary_driver": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "primary_conflict": {"label": "Weekly tape", "score": 30.62246702982886, "score_label": "31", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 31/100 tape read.", "detail": "", "metric": "31/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.6}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 30.62246702982886, "score_label": "31", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 31/100 tape read.", "detail": "", "metric": "31/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 34.13194444444444, "score_label": "34", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/12, activity pressure 10/12, relative leadership 0/12.", "detail": "Activity pressure 0.45; No reversal markers", "metric": "34/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.45}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 43.0, "score_label": "43", "tone": "neutral", "summary": "Weighted news tone is neutral across 7 relevant articles.", "detail": "Oryzon Q2 Results: Net Loss Narrows as Iadademstat Shows 100% ORR", "metric": "43/100", "url": "/sentiment/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Weekly tape", "score": 30.62246702982886, "score_label": "31", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 31/100 tape read.", "detail": "", "metric": "31/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 34.13194444444444, "score_label": "34", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/12, activity pressure 10/12, relative leadership 0/12.", "detail": "Activity pressure 0.45; No reversal markers", "metric": "34/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.45}], "conclusion": ["The strongest supporting evidence is patient capital: Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "The main constraint is weekly tape: Trend, activity pressure, participation, and risk combine to a 31/100 tape read.", "The combined read is defensive, so risk control and evidence of stabilization matter more than headline upside."], "weekly_changes": [{"label": "Price follow-through", "value": "-0.1%", "detail": "Latest completed week; four-week move 1.2%.", "tone": "negative", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Indicator stack", "value": "25/46", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "43/100", "detail": "7 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/2343b247-36a5-4b4e-89e3-a59397cef98f/"}]}, "investor_view": {"stance": "Mixed setup", "stance_tone": "neutral", "setup_score": "34", "bottom_line": "The weekly trend is not active. Price is -1.9% below the Trend Line and sits at 23.4% of its 52-week range. The latest completed week returned -0.1%, after a 1.2% four-week move. The latest news-sentiment score is 43/100. Near-term considerations: volume confirmation is below normal.", "price_summary": "The weekly trend is not active. Price is -1.9% below the Trend Line and sits at 23.4% of its 52-week range. The latest completed week returned -0.1%, after a 1.2% four-week move.", "volume_summary": "Latest weekly volume is 0.8x the 13-week average. Participation is below its recent norm, so price strength is not receiving full volume confirmation.", "momentum_summary": "Performance is 1.2% over four weeks, 3.4% over 12 weeks, and 10.2% over one year. The current trend has remained active for 0 consecutive weeks.", "fundamentals": {"available": false, "summary": "A published fundamentals and factor snapshot is not available for this company.", "rank_scores": [], "groups": []}, "weekly_change": [{"label": "Price follow-through", "value": "-0.1%", "detail": "Latest completed week; four-week move 1.2%.", "tone": "negative", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Indicator stack", "value": "25/46", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "43/100", "detail": "7 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/2343b247-36a5-4b4e-89e3-a59397cef98f/"}], "strengths": ["Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is positive on the latest completed week."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below the Trend Line, which keeps downside pressure in focus.", "Activity pressure is weak, so confirmation is not yet broad enough.", "The share remains more than 20% below its 52-week high."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "evidence": {"weekly_tape": {"label": "Weekly tape", "score": 30.62246702982886, "score_label": "31", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 31/100 tape read.", "detail": "", "metric": "31/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.6}, "indicator_analysis": {"label": "Indicator analysis", "score": 34.13194444444444, "score_label": "34", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/12, activity pressure 10/12, relative leadership 0/12.", "detail": "Activity pressure 0.45; No reversal markers", "metric": "34/100", "url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 1.45}, "factors": {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, "patient_capital": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "sentiment": {"label": "Sentiment", "score": 43.0, "score_label": "43", "tone": "neutral", "summary": "Weighted news tone is neutral across 7 relevant articles.", "detail": "Oryzon Q2 Results: Net Loss Narrows as Iadademstat Shows 100% ORR", "metric": "43/100", "url": "/sentiment/2343b247-36a5-4b4e-89e3-a59397cef98f/", "available": true, "weight": 0.95}, "insiders": {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, "earnings": {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}}, "section_nav": [{"id": "overview", "label": "Overview"}, {"id": "price-action", "label": "Price"}, {"id": "volume-demand", "label": "Volume"}, {"id": "momentum", "label": "Momentum"}, {"id": "fundamentals", "label": "Fundamentals"}, {"id": "ownership-flow", "label": "Ownership & Flow"}, {"id": "catalysts-risk", "label": "Catalysts & Risk"}, {"id": "peer-context", "label": "Peer Context"}, {"id": "weekly-data", "label": "Weekly Data"}]}, "chart_url": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/", "api_path": "/terminal/2343b247-36a5-4b4e-89e3-a59397cef98f/report/api/"}