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Its lead drug candidate is HTD1801, which is in phase III clinical trial to treat type 2 diabetes mellitus (T2DM); in phase IIb clinical trial to treat metabolic dysfunction-associated steatohepatitis (MASH); in phase II clinical trial to treat severe hypertriglyceridemia; and in phase II clinical trial to treat primary sclerosing cholangitis, as well as in phase II clinical trial to treat primary biliary cholangitis. The company is also developing HTD4010, a polypeptide drug, which is in phase I clinical trial for the treatment of alcoholic hepatitis; HTD1804 that is in preclinical trial to treat obesity; HTD1805, a multifunctional small molecule drug, which is in preclinical trial for the treatment of metabolic diseases; HTF1057 a preclinical-stage a drug candidate for the treatment of neurodegenerative diseases; HTF1037 a preclinical-stage for the treatment of obesity and comorbidities; and HTD2802 that is in preclinical trial for treating inflammatory bowel disease. HighTide Therapeutics, Inc. was founded in 2011 and is headquartered in Shenzhen, China.", "setup_signature": "Balanced read", "composite_score": "56", "kpis": [{"label": "Latest Close", "value": "3.40 HKD", "hint": "2026-08-07"}, {"label": "1W Return", "value": "30.8%", "tone": "positive", "hint": "latest completed week"}, {"label": "4W Return", "value": "29.3%", "tone": "positive", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "-10.8%", "tone": "negative", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "40.4%", "hint": "21 of 52 weeks active"}, {"label": "Volume Ratio", "value": "4.2x", "hint": "vs 13-week average"}], "classification": {"exchange": "HKG", "country": "HK", "sector": "Healthcare", "industry": "Biotechnology", "currency": "HKD", "market_cap": "1.5B"}, "price": {"trend_line": "3.02 HKD", "fair_value": "3.49 HKD", "vs_trend": "12.6%", "vs_fair_value": "-2.7%", "high_52": "4.72 HKD", "low_52": "1.80 HKD", "drawdown": "-28.0%", 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"-1.9%", "return_tone": "negative", "volume_height": 4, "volume": "371.1K"}, {"week": "7 Aug", "return": 30.76923076923076, "return_label": "30.8%", "return_tone": "positive", "volume_height": 39.89498637211304, "volume": "5.6M"}], "insights": [{"label": "Participation", "value": "4.2x", "detail": "Latest volume versus the 13-week average.", "tone": "positive"}, {"label": "Baseline", "value": "1.3M", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "3.8M", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "10.3%", "volatility_52": "9.2%", "downside_weeks": 28, "upside_weeks": 23, "downside_breadth": "53.8%", "average_gain": "8.2%", "average_loss": "-5.8%", "distribution_scale": "31%", "return_callouts": [{"label": "Weeks higher", "value": "13 of 26", "detail": "13 weeks finished lower.", "tone": "negative"}, {"label": "Best week", "value": "+30.8%", "detail": "Week of 7 Aug.", "tone": "positive"}, {"label": "Worst week", "value": "-12.5%", "detail": "Week of 27 Feb.", "tone": "negative"}, {"label": "Latest week", "value": "+30.8%", "detail": "Week of 7 Aug.", "tone": "positive"}], "buckets": [{"label": "Strong gains", "count": 7, "share": 26.923076923076923, "share_label": "26.9%", "tone": "positive"}, {"label": "Modest gains", "count": 6, "share": 23.076923076923077, "share_label": "23.1%", "tone": "positive"}, {"label": "Flat weeks", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "neutral"}, {"label": "Modest losses", "count": 4, "share": 15.384615384615385, "share_label": "15.4%", "tone": "negative"}, {"label": "Sharp losses", "count": 9, "share": 34.61538461538461, "share_label": "34.6%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "10.3%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "9.2%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "23/28", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "negative"}, {"label": "Average skew", "value": "8.2% / -5.8%", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Inactive", "tone": "negative"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "12.6%", "tone": "positive"}, {"label": "Volume", "value": "4.2x", "tone": "positive"}], "opportunities": ["Price is above the Trend Line, keeping the weekly tape constructive.", "Volume is elevated versus the 13-week average, confirming attention."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below Fair Value, so the market is still discounting the latest tape.", "Activity pressure is negative, which weakens the current setup.", "Activity pressure is weak, so confirmation is not yet broad enough.", "The share remains more than 20% below its 52-week high."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-08-07", "close": "3.40 HKD", "return": null, "return_tone": null, "trend_line": "3.02 HKD", "fair_value": "3.49 HKD", "activity_pressure": "-0.69", "relative_leadership": "7.84", "volume": "5.6M", "trend_backdrop": null}, {"week": "2026-07-31", "close": "2.60 HKD", "return": null, "return_tone": null, "trend_line": "3.00 HKD", "fair_value": "3.49 HKD", "activity_pressure": "-0.99", "relative_leadership": "-18.18", "volume": "371.1K", "trend_backdrop": null}, {"week": "2026-07-24", "close": "2.65 HKD", "return": null, "return_tone": null, "trend_line": "3.01 HKD", "fair_value": "3.50 HKD", "activity_pressure": "-0.98", "relative_leadership": "-13.87", "volume": "1.1M", "trend_backdrop": null}, {"week": "2026-07-17", "close": "2.60 HKD", "return": null, "return_tone": null, "trend_line": "3.02 HKD", "fair_value": "3.51 HKD", "activity_pressure": "-1.00", "relative_leadership": "-14.56", "volume": "713.5K", "trend_backdrop": null}, {"week": "2026-07-10", "close": "2.63 HKD", "return": null, "return_tone": null, "trend_line": "3.03 HKD", "fair_value": "3.51 HKD", "activity_pressure": "-0.92", "relative_leadership": "-12.73", "volume": "510.5K", "trend_backdrop": null}, {"week": "2026-07-03", "close": "2.74 HKD", "return": null, "return_tone": null, "trend_line": "3.03 HKD", "fair_value": "3.52 HKD", "activity_pressure": "-0.82", "relative_leadership": "-6.40", "volume": "68.5K", "trend_backdrop": null}, {"week": "2026-06-26", "close": "2.69 HKD", "return": null, "return_tone": null, "trend_line": "3.04 HKD", "fair_value": "3.53 HKD", "activity_pressure": "-0.67", "relative_leadership": "-5.31", "volume": "426.5K", "trend_backdrop": null}, {"week": "2026-06-19", "close": "2.97 HKD", "return": null, "return_tone": null, "trend_line": "3.04 HKD", "fair_value": "3.53 HKD", "activity_pressure": "-0.45", "relative_leadership": "-0.85", "volume": "2.0M", "trend_backdrop": null}, {"week": "2026-06-12", "close": "2.86 HKD", "return": null, "return_tone": null, "trend_line": "3.04 HKD", "fair_value": "3.54 HKD", "activity_pressure": "-0.18", "relative_leadership": "-7.56", "volume": "234.5K", "trend_backdrop": null}, {"week": "2026-06-05", "close": "2.99 HKD", "return": null, "return_tone": null, "trend_line": "3.04 HKD", "fair_value": "3.54 HKD", "activity_pressure": "0.20", "relative_leadership": "-4.59", "volume": "159.5K", "trend_backdrop": null}, {"week": "2026-05-29", "close": "3.05 HKD", "return": null, "return_tone": null, "trend_line": "3.05 HKD", "fair_value": "3.55 HKD", "activity_pressure": "0.71", "relative_leadership": "-3.38", "volume": "2.6M", "trend_backdrop": null}, {"week": "2026-05-22", "close": "3.42 HKD", "return": null, "return_tone": null, "trend_line": "3.08 HKD", "fair_value": "3.55 HKD", "activity_pressure": "1.02", "relative_leadership": "7.06", "volume": "1.9M", "trend_backdrop": null}, {"week": "2026-05-15", "close": "3.81 HKD", "return": null, "return_tone": null, "trend_line": "3.08 HKD", "fair_value": "3.55 HKD", "activity_pressure": "1.24", "relative_leadership": "17.90", "volume": "1.7M", "trend_backdrop": null}, {"week": "2026-05-08", "close": "4.14 HKD", "return": null, "return_tone": null, "trend_line": "3.07 HKD", "fair_value": "3.55 HKD", "activity_pressure": "1.35", "relative_leadership": "26.20", "volume": "12.2M", "trend_backdrop": null}], "intelligence": {"rating": "Neutral", "rating_tone": "neutral", "overall_score": "43", "primary_driver": {"label": "Sentiment", "score": 56.0, "score_label": "56", "tone": "neutral", "summary": "Weighted news tone is neutral across 3 relevant articles.", "detail": "Hightide Therapeutics Inc Revenue Breakdown \u2013 HKEX:2511", "metric": "56/100", "url": "/sentiment/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 0.95}, "primary_conflict": {"label": "Indicator analysis", "score": 27.437499999999993, "score_label": "27", "tone": "negative", "summary": "Latest 12-week confirmation: trend 4/12, activity pressure 3/12, relative leadership 2/12.", "detail": "Activity pressure 0.13; No reversal markers", "metric": "27/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.45}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 47.20952181468917, "score_label": "47", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 47/100 tape read.", "detail": "", "metric": "47/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 27.437499999999993, "score_label": "27", "tone": "negative", "summary": "Latest 12-week confirmation: trend 4/12, activity pressure 3/12, relative leadership 2/12.", "detail": "Activity pressure 0.13; No reversal markers", "metric": "27/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.45}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 56.0, "score_label": "56", "tone": "neutral", "summary": "Weighted news tone is neutral across 3 relevant articles.", "detail": "Hightide Therapeutics Inc Revenue Breakdown \u2013 HKEX:2511", "metric": "56/100", "url": "/sentiment/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Indicator analysis", "score": 27.437499999999993, "score_label": "27", "tone": "negative", "summary": "Latest 12-week confirmation: trend 4/12, activity pressure 3/12, relative leadership 2/12.", "detail": "Activity pressure 0.13; No reversal markers", "metric": "27/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.45}], "conclusion": ["The strongest supporting evidence is sentiment: Weighted news tone is neutral across 3 relevant articles.", "The main constraint is indicator analysis: Latest 12-week confirmation: trend 4/12, activity pressure 3/12, relative leadership 2/12.", "The combined read is balanced, making the next change in trend, sentiment, or options pressure especially important."], "weekly_changes": [{"label": "Price follow-through", "value": "30.8%", "detail": "Latest completed week; four-week move 29.3%.", "tone": "positive", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Indicator stack", "value": "22/40", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "56/100", "detail": "3 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}]}, "investor_view": {"stance": "Mixed setup", "stance_tone": "neutral", "setup_score": "56", "bottom_line": "The weekly trend is not active. Price is 12.6% above the Trend Line and sits at 54.8% of its 52-week range. The latest completed week returned 30.8%, after a 29.3% four-week move. The latest news-sentiment score is 56/100.", "price_summary": "The weekly trend is not active. Price is 12.6% above the Trend Line and sits at 54.8% of its 52-week range. The latest completed week returned 30.8%, after a 29.3% four-week move.", "volume_summary": "Latest weekly volume is 4.2x the 13-week average. Participation is unusually strong and confirms that the move is attracting attention.", "momentum_summary": "Performance is 29.3% over four weeks, -10.8% over 12 weeks, and 5.9% over one year. The current trend has remained active for 0 consecutive weeks.", "fundamentals": {"available": false, "summary": "A published fundamentals and factor snapshot is not available for this company.", "rank_scores": [], "groups": []}, "weekly_change": [{"label": "Price follow-through", "value": "30.8%", "detail": "Latest completed week; four-week move 29.3%.", "tone": "positive", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Indicator stack", "value": "22/40", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "56/100", "detail": "3 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/3455c0f6-a0fb-4198-942a-77c63e1989a5/"}], "strengths": ["Price is above the Trend Line, keeping the weekly tape constructive.", "Volume is elevated versus the 13-week average, confirming attention."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below Fair Value, so the market is still discounting the latest tape.", "Activity pressure is negative, which weakens the current setup.", "Activity pressure is weak, so confirmation is not yet broad enough."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "evidence": {"weekly_tape": {"label": "Weekly tape", "score": 47.20952181468917, "score_label": "47", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 47/100 tape read.", "detail": "", "metric": "47/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.6}, "indicator_analysis": {"label": "Indicator analysis", "score": 27.437499999999993, "score_label": "27", "tone": "negative", "summary": "Latest 12-week confirmation: trend 4/12, activity pressure 3/12, relative leadership 2/12.", "detail": "Activity pressure 0.13; No reversal markers", "metric": "27/100", "url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 1.45}, "factors": {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, "patient_capital": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "sentiment": {"label": "Sentiment", "score": 56.0, "score_label": "56", "tone": "neutral", "summary": "Weighted news tone is neutral across 3 relevant articles.", "detail": "Hightide Therapeutics Inc Revenue Breakdown \u2013 HKEX:2511", "metric": "56/100", "url": "/sentiment/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "available": true, "weight": 0.95}, "insiders": {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, "earnings": {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}}, "section_nav": [{"id": "overview", "label": "Overview"}, {"id": "price-action", "label": "Price"}, {"id": "volume-demand", "label": "Volume"}, {"id": "momentum", "label": "Momentum"}, {"id": "fundamentals", "label": "Fundamentals"}, {"id": "ownership-flow", "label": "Ownership & Flow"}, {"id": "catalysts-risk", "label": "Catalysts & Risk"}, {"id": "peer-context", "label": "Peer Context"}, {"id": "weekly-data", "label": "Weekly Data"}]}, "chart_url": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/", "api_path": "/terminal/3455c0f6-a0fb-4198-942a-77c63e1989a5/report/api/"}