{"ticker": {"uuid": "62a5460f-1b30-4614-a90f-00d675677e6d", "symbol": "R2AR34", "name": "Ultragenyx Pharmaceutical Inc.", "exchange": "SAO", "asset_type": "equity"}, "latest_week": "2026-07-03", "summary": "R2AR34 closed the latest completed week at 17.08 BRL. The 4-week return is - and the 12-week return is -. The trend backdrop is inactive, with activity pressure at 0.00.", "description": "Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Latin America, Europe, the Middle East, Africa, and the Asia-Pacific. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the treatment of children and adults with Mucopolysaccharidosis VII; Dojolvi for the treatment of long-chain fatty acid oxidation disorders; and Evkeeza (evinacumab) for the treatment of homozygous familial hypercholesterolemia. The company's products candidates that are in Phase 3 clinical trials include UX143, a human monoclonal antibody for the treatment of osteogenesis imperfecta; UX111, an AAV9 gene therapy product candidate for the treatment of patients with Sanfilippo syndrome type A, or MPS IIIA, a rare lysosomal storage disease; DTX401, an adeno-associated virus 8 (AAV8) gene therapy clinical candidate for the treatment of patients with glycogen storage disease type Ia; DTX301, an AAV8 gene therapy for the treatment of patients with ornithine transcarbamylase; and GTX-102, an antisense oligonucleotide for the treatment of Angelman syndrome. It also develops UX701, an adeno-associated AAV9 gene therapy which is in Phase 2 clinical trial for the treatment of Wilson liver disease. The company has collaboration and license agreement with Kyowa Kirin Co., Ltd.; Saint Louis University; Baylor Research Institute; REGENXBIO Inc.; GeneTx; Mereo; University of Pennsylvania; Regeneron; and Abeona. Ultragenyx Pharmaceutical Inc. was incorporated in 2010 and is headquartered in Novato, California.", "setup_signature": "Balanced read", "composite_score": "42", "kpis": [{"label": "Latest Close", "value": "17.08 BRL", "hint": "2026-07-03"}, {"label": "1W Return", "value": "42.5%", "tone": "positive", "hint": "latest completed week"}, {"label": "4W Return", "value": "-", "tone": "neutral", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "-", "tone": "neutral", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "0.0%", "hint": "0 of 4 weeks active"}, {"label": "Volume Ratio", "value": "4.0x", "hint": "vs 13-week average"}], "classification": {"exchange": "SAO", "country": "BR", "sector": "Healthcare", "industry": "Biotechnology", "currency": "BRL", "market_cap": "1.7B"}, "price": {"trend_line": "-", "fair_value": "13.26 BRL", "vs_trend": "-", "vs_fair_value": "28.8%", "high_52": "18.02 BRL", "low_52": "11.87 BRL", "drawdown": "-5.2%", 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change in relative leadership.", "tone": "neutral"}]}, "indicators": {"available": true, "activity_pressure_latest": "0.20", "activity_pressure_average": "0.20", "activity_pressure_positive_count": 0, "activity_pressure_bars": [{"value": null, "value_label": "-", "height": 4, "tone": "neutral"}, {"value": null, "value_label": "-", "height": 4, "tone": "neutral"}, {"value": null, "value_label": "-", "height": 4, "tone": "neutral"}, {"value": 0.2, "value_label": "0.20", "height": 20.0, "tone": "negative"}], "activity_pressure_points": "100.00,22.00", "expectancy_points": "66.67,22.00 100.00,22.00", "expectancy_bars": [{"value": null, "value_label": "-", "height": 4, "tone": "neutral"}, {"value": null, "value_label": "-", "height": 4, "tone": "neutral"}, {"value": -0.0, "value_label": "-0.00", "height": 4, "tone": "neutral"}, {"value": -0.0, "value_label": "-0.00", "height": 4, "tone": "neutral"}], "confirmation": [{"label": "Trend active", "value": "0/4", "detail": "Active trend-backdrop 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"1 reversal markers"}}, "volume": {"latest": "4.7K", "average_13": "1.2K", "average_52": "1.2K", "ratio_13": "4.0x", "ratio_52": "4.0x", "confirmation": [{"week": "12 Jun", "return": null, "return_label": "-", "return_tone": "neutral", "volume_height": 4, "volume": "38"}, {"week": "19 Jun", "return": 0.0, "return_label": "0.0%", "return_tone": "neutral", "volume_height": 4, "volume": "0"}, {"week": "26 Jun", "return": 0.0, "return_label": "0.0%", "return_tone": "neutral", "volume_height": 4, "volume": "0"}, {"week": "3 Jul", "return": 42.452043369474545, "return_label": "42.5%", "return_tone": "positive", "volume_height": 100, "volume": "4.7K"}], "insights": [{"label": "Participation", "value": "4.0x", "detail": "Latest volume versus the 13-week average.", "tone": "positive"}, {"label": "Baseline", "value": "1.2K", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "1.2K", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "20.0%", "volatility_52": "20.0%", "downside_weeks": 0, "upside_weeks": 1, "downside_breadth": "0.0%", "average_gain": "42.5%", "average_loss": "-", "buckets": [{"label": "Strong gains", "count": 1, "share": 33.33333333333333, "share_label": "33.3%", "tone": "positive"}, {"label": "Modest gains", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "positive"}, {"label": "Flat weeks", "count": 2, "share": 66.66666666666666, "share_label": "66.7%", "tone": "neutral"}, {"label": "Modest losses", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "negative"}, {"label": "Sharp losses", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "20.0%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "20.0%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "1/0", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "positive"}, {"label": "Average skew", "value": "42.5% / -", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Inactive", "tone": "negative"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "-", "tone": "neutral"}, {"label": "Volume", "value": "4.0x", "tone": "positive"}], "opportunities": ["Price is above Fair Value, showing premium demand versus the model.", "Volume is elevated versus the 13-week average, confirming attention.", "Latest weekly return ranks in the strongest part of its sector group."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Activity pressure is negative, which weakens the current setup.", "Next-week expectancy is negative at 0.00% based on similar historical setup states.", "Activity pressure is weak, so confirmation is not yet broad enough.", "1 reversal markers appear in the recent smart-money tape."], "watch_points": ["Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-07-03", "close": "17.08 BRL", "return": null, "return_tone": null, "trend_line": "-", "fair_value": "13.26 BRL", "activity_pressure": "0.00", "relative_leadership": "-", "volume": "4.7K", "trend_backdrop": null}, {"week": "2026-06-26", "close": "11.99 BRL", "return": null, "return_tone": null, "trend_line": "-", "fair_value": "11.99 BRL", "activity_pressure": "-", "relative_leadership": "-", "volume": "0", "trend_backdrop": null}, {"week": "2026-06-19", "close": "11.99 BRL", "return": null, "return_tone": null, "trend_line": "-", "fair_value": "11.99 BRL", "activity_pressure": "-", "relative_leadership": "-", "volume": "0", "trend_backdrop": null}, {"week": "2026-06-12", "close": "11.99 BRL", "return": null, "return_tone": null, "trend_line": "-", "fair_value": "11.99 BRL", "activity_pressure": "-", "relative_leadership": "-", "volume": "38", "trend_backdrop": null}], "intelligence": {"rating": "Caution", "rating_tone": "negative", "overall_score": "36", "primary_driver": {"label": "Next-Week Expectancy", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "Next-week expectancy is negative with a 0.00% historical one-week setup read.", "detail": "Adds short-term historical context without overriding trend, activity, or relative leadership.", "metric": "Negative 0.00%", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.05}, "primary_conflict": {"label": "Indicator analysis", "score": 10.083333333333332, "score_label": "10", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/4, activity pressure 0/4, relative leadership 0/4.", "detail": "Activity pressure 0.20; 1 reversal markers", "metric": "10/100", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.45}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 37.50416270278004, "score_label": "38", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 38/100 tape read.", "detail": "", "metric": "38/100", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 10.083333333333332, "score_label": "10", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/4, activity pressure 0/4, relative leadership 0/4.", "detail": "Activity pressure 0.20; 1 reversal markers", "metric": "10/100", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.45}, {"label": "Next-Week Expectancy", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "Next-week expectancy is negative with a 0.00% historical one-week setup read.", "detail": "Adds short-term historical context without overriding trend, activity, or relative leadership.", "metric": "Negative 0.00%", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.05}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Weighted news tone is neutral across 8 relevant articles.", "detail": "Ultragenyx: The Setrusumab Reset Creates A Cleaner Rare Disease Opportunity", "metric": "48/100", "url": "/sentiment/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Indicator analysis", "score": 10.083333333333332, "score_label": "10", "tone": "negative", "summary": "Latest 12-week confirmation: trend 0/4, activity pressure 0/4, relative leadership 0/4.", "detail": "Activity pressure 0.20; 1 reversal markers", "metric": "10/100", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.45}, {"label": "Weekly tape", "score": 37.50416270278004, "score_label": "38", "tone": "negative", "summary": "Trend, activity pressure, participation, and risk combine to a 38/100 tape read.", "detail": "", "metric": "38/100", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "available": true, "weight": 1.6}], "conclusion": ["The strongest supporting evidence is next-week expectancy: Next-week expectancy is negative with a 0.00% historical one-week setup read.", "The main constraint is indicator analysis: Latest 12-week confirmation: trend 0/4, activity pressure 0/4, relative leadership 0/4.", "The combined read is defensive, so risk control and evidence of stabilization matter more than headline upside."], "weekly_changes": [{"label": "Price follow-through", "value": "42.5%", "detail": "Latest completed week; four-week move -.", "tone": "positive", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/"}, {"label": "Indicator stack", "value": "0/50", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "Next-Week Expectancy", "value": "Negative 0.00%", "detail": "Historical one-week expectancy contributes to the evidence score when direction is confirmed.", "tone": "negative", "url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/"}, {"label": "News sentiment", "value": "48/100", "detail": "8 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/62a5460f-1b30-4614-a90f-00d675677e6d/"}]}, "chart_url": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/", "api_path": "/terminal/62a5460f-1b30-4614-a90f-00d675677e6d/report/api/"}