{"ticker": {"uuid": "b309d90c-cf8b-4611-987a-e98f323e131b", "symbol": "4528", "name": "Ono Pharmaceutical Co., Ltd.", "exchange": "JPX", "asset_type": "equity"}, "latest_week": "2026-08-07", "summary": "4528 closed the latest completed week at 2,380 JPY. The 4-week return is -2.0% and the 12-week return is -6.0%. The trend backdrop is inactive, with activity pressure at -0.24.", "description": "Ono Pharmaceutical Co., Ltd. produces, purchases, and sells pharmaceuticals and diagnostic reagents worldwide. It offers Opdivo intravenous infusion and Kyprolis intravenous injection for malignant tumors; Emend capsule intravenous injections for chemotherapy-induced nausea and vomiting; Demser capsules for the symptoms in patients with pheochromocytoma; Mektovi, Velexbru, and Braftovi capsules for malignant tumors; and ADLUMIZ tablets for cancer cachexia. The company also provides Glactiv tablets for type 2 diabetes; Forxiga tablets for diabetes, chronic heart failure, and chronic kidney disease; Onoact intravenous infusion for tachyarrhythmia; Opalmon tablets to treat peripheral circulatory disorder; Coralan for chronic heart failure; Orencia injections for rheumatoid arthritis; Rivastach patches for Alzheimer's disease; Ongentys tablets for Parkinson's disease; Parsabiv for the treatment of secondary hyperparathyroidism; Staybla tablets for overactive bladder; Onon capsules and Dry Syrups for bronchial asthma and allergic rhinitis; and Joyclu intra-articular injection for the improvement of joint function, as well as Recalbon tablets for osteoporosis. In addition, it develops products for hepatocellular and urothelial carcinoma; ovarian, bladder, prostate, pancreatic, gastric, esophageal, colorectal, thyroid, cell lung, and breast cancer; acute myeloid leukemia; solid tumors; myelodysplastic syndrome; melanoma; T-cell lymphoma; tachyarrhythmia; pemphigus; scleroderma; seizures; diabetic polyneuropathy; neurodegenerative diseases; autoimmune diseases; narcolepsy; and thrombosis. The company has collaborations with Adimab LLC; Turbine Ltd.; Harvard University; Sibylla Biotech; and Congruence Therapeutics. Ono Pharmaceutical Co., Ltd. was founded in 1717 and is headquartered in Osaka, Japan.", "setup_signature": "Balanced read", "composite_score": "49", "kpis": [{"label": "Latest Close", "value": "2,380 JPY", "hint": "2026-08-07"}, {"label": "1W Return", "value": "-0.1%", "tone": "negative", "hint": "latest completed week"}, {"label": "4W Return", "value": "-2.0%", "tone": "negative", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "-6.0%", "tone": "negative", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "82.7%", "hint": "43 of 52 weeks active"}, {"label": "Volume Ratio", "value": "1.4x", "hint": "vs 13-week average"}], "classification": {"exchange": "JPX", "country": "JP", "sector": "Healthcare", "industry": "Drug Manufacturers - General", "currency": "JPY", "market_cap": "1124.3B"}, "price": {"trend_line": "2,402 JPY", "fair_value": "2,024 JPY", "vs_trend": "-0.9%", "vs_fair_value": "17.6%", "high_52": "2,633 JPY", "low_52": "1,534 JPY", 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"1.1M"}, {"week": "10 Jul", "return": 0.37205456800330716, "return_label": "0.4%", "return_tone": "positive", "volume_height": 46.28561240862899, "volume": "6.5M"}, {"week": "17 Jul", "return": -0.10296540362438221, "return_label": "-0.1%", "return_tone": "negative", "volume_height": 53.86486004635407, "volume": "7.6M"}, {"week": "24 Jul", "return": 0.3916718202432488, "return_label": "0.4%", "return_tone": "positive", "volume_height": 37.920484934926016, "volume": "5.3M"}, {"week": "31 Jul", "return": -2.0944558521560577, "return_label": "-2.1%", "return_tone": "negative", "volume_height": 74.76698163665537, "volume": "10.5M"}, {"week": "7 Aug", "return": -0.14681208053691275, "return_label": "-0.1%", "return_tone": "negative", "volume_height": 59.04938491709753, "volume": "8.3M"}], "insights": [{"label": "Participation", "value": "1.4x", "detail": "Latest volume versus the 13-week average.", "tone": "neutral"}, {"label": "Baseline", "value": "5.7M", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "10.3M", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "3.0%", "volatility_52": "3.4%", "downside_weeks": 22, "upside_weeks": 30, "downside_breadth": "42.3%", "average_gain": "2.9%", "average_loss": "-2.2%", "distribution_scale": "9%", "return_callouts": [{"label": "Weeks higher", "value": "12 of 26", "detail": "14 weeks finished lower.", "tone": "negative"}, {"label": "Best week", "value": "+8.5%", "detail": "Week of 27 Mar.", "tone": "positive"}, {"label": "Worst week", "value": "-7.0%", "detail": "Week of 5 Jun.", "tone": "negative"}, {"label": "Latest week", "value": "-0.1%", "detail": "Week of 7 Aug.", "tone": "negative"}], "buckets": [{"label": "Strong gains", "count": 3, "share": 11.538461538461538, "share_label": "11.5%", "tone": "positive"}, {"label": "Modest gains", "count": 9, "share": 34.61538461538461, "share_label": "34.6%", "tone": "positive"}, {"label": "Flat weeks", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "neutral"}, {"label": "Modest losses", "count": 10, "share": 38.46153846153847, "share_label": "38.5%", "tone": "negative"}, {"label": "Sharp losses", "count": 4, "share": 15.384615384615385, "share_label": "15.4%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "3.0%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "3.4%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "30/22", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "positive"}, {"label": "Average skew", "value": "2.9% / -2.2%", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Inactive", "tone": "negative"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "-0.9%", "tone": "negative"}, {"label": "Volume", "value": "1.4x", "tone": "neutral"}], "opportunities": ["Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is constructive, supporting the smart-money activity read."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below the Trend Line, which keeps downside pressure in focus.", "Activity pressure is negative, which weakens the current setup.", "2 reversal markers appear in the recent smart-money tape."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-08-07", "close": "2,380 JPY", "return": null, "return_tone": null, "trend_line": "2,402 JPY", "fair_value": "2,024 JPY", "activity_pressure": "-0.24", "relative_leadership": "-8.55", "volume": "8.3M", "trend_backdrop": null}, {"week": "2026-07-31", "close": "2,384 JPY", "return": null, "return_tone": null, "trend_line": "2,397 JPY", "fair_value": "2,025 JPY", "activity_pressure": "-0.37", "relative_leadership": "-6.78", "volume": "10.5M", "trend_backdrop": null}, {"week": "2026-07-24", "close": "2,435 JPY", "return": null, "return_tone": null, "trend_line": "2,389 JPY", "fair_value": "2,025 JPY", "activity_pressure": "-0.64", "relative_leadership": "-5.23", "volume": "5.3M", "trend_backdrop": null}, {"week": "2026-07-17", "close": "2,426 JPY", "return": null, "return_tone": null, "trend_line": "2,380 JPY", "fair_value": "2,024 JPY", "activity_pressure": "-0.82", "relative_leadership": "-4.91", "volume": "7.6M", "trend_backdrop": null}, {"week": "2026-07-10", "close": "2,428 JPY", "return": null, "return_tone": null, "trend_line": "2,370 JPY", "fair_value": "2,024 JPY", "activity_pressure": "-1.13", "relative_leadership": "-10.98", "volume": "6.5M", "trend_backdrop": null}, {"week": "2026-07-03", "close": "2,419 JPY", "return": null, "return_tone": null, "trend_line": "2,361 JPY", "fair_value": "2,023 JPY", "activity_pressure": "-1.42", "relative_leadership": "-12.98", "volume": "1.1M", "trend_backdrop": null}, {"week": "2026-06-26", "close": "2,378 JPY", "return": null, "return_tone": null, "trend_line": "2,349 JPY", "fair_value": "2,021 JPY", "activity_pressure": "-1.56", "relative_leadership": "-14.15", "volume": "1.4M", "trend_backdrop": null}, {"week": "2026-06-19", "close": "2,249 JPY", "return": null, "return_tone": null, "trend_line": "2,342 JPY", "fair_value": "2,021 JPY", "activity_pressure": "-1.58", "relative_leadership": "-21.04", "volume": "2.2M", "trend_backdrop": null}, {"week": "2026-06-12", "close": "2,212 JPY", "return": null, "return_tone": null, "trend_line": "2,335 JPY", "fair_value": "2,022 JPY", "activity_pressure": "-1.35", "relative_leadership": "-16.47", "volume": "1.9M", "trend_backdrop": null}, {"week": "2026-06-05", "close": "2,225 JPY", "return": null, "return_tone": null, "trend_line": "2,328 JPY", "fair_value": "2,024 JPY", "activity_pressure": "-1.05", "relative_leadership": "-16.96", "volume": "1.6M", "trend_backdrop": null}, {"week": "2026-05-29", "close": "2,392 JPY", "return": null, "return_tone": null, "trend_line": "2,318 JPY", "fair_value": "2,025 JPY", "activity_pressure": "-0.82", "relative_leadership": "-10.56", "volume": "8.6M", "trend_backdrop": null}, {"week": "2026-05-22", "close": "2,482 JPY", "return": null, "return_tone": null, "trend_line": "2,299 JPY", "fair_value": "2,025 JPY", "activity_pressure": "-0.88", "relative_leadership": "-2.98", "volume": "9.6M", "trend_backdrop": null}, {"week": "2026-05-15", "close": "2,534 JPY", "return": null, "return_tone": null, "trend_line": "2,277 JPY", "fair_value": "2,024 JPY", "activity_pressure": "-0.98", "relative_leadership": "2.08", "volume": "9.7M", "trend_backdrop": null}, {"week": "2026-05-08", "close": "2,480 JPY", "return": null, "return_tone": null, "trend_line": "2,252 JPY", "fair_value": "2,022 JPY", "activity_pressure": "-1.07", "relative_leadership": "-2.01", "volume": "7.9M", "trend_backdrop": null}], "intelligence": {"rating": "Caution", "rating_tone": "negative", "overall_score": "42", "primary_driver": {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 15 relevant articles.", "detail": "Ono Pharmaceutical Co., Ltd. 2027 Q1 - Results - Earnings Call Presentation (OTCMKTS:OPHLY) 2026-08-04", "metric": "54/100", "url": "/sentiment/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 0.95}, "primary_conflict": {"label": "Indicator analysis", "score": 22.208333333333332, "score_label": "22", "tone": "negative", "summary": "Latest 12-week confirmation: trend 3/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.62; 2 reversal markers", "metric": "22/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.45}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 49.529493134442696, "score_label": "50", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 50/100 tape read.", "detail": "", "metric": "50/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 22.208333333333332, "score_label": "22", "tone": "negative", "summary": "Latest 12-week confirmation: trend 3/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.62; 2 reversal markers", "metric": "22/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.45}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 15 relevant articles.", "detail": "Ono Pharmaceutical Co., Ltd. 2027 Q1 - Results - Earnings Call Presentation (OTCMKTS:OPHLY) 2026-08-04", "metric": "54/100", "url": "/sentiment/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Indicator analysis", "score": 22.208333333333332, "score_label": "22", "tone": "negative", "summary": "Latest 12-week confirmation: trend 3/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.62; 2 reversal markers", "metric": "22/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.45}], "conclusion": ["The strongest supporting evidence is sentiment: Weighted news tone is neutral across 15 relevant articles.", "The main constraint is indicator analysis: Latest 12-week confirmation: trend 3/12, activity pressure 0/12, relative leadership 0/12.", "The combined read is defensive, so risk control and evidence of stabilization matter more than headline upside."], "weekly_changes": [{"label": "Price follow-through", "value": "-0.1%", "detail": "Latest completed week; four-week move -2.0%.", "tone": "negative", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Indicator stack", "value": "45/52", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "neutral", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "54/100", "detail": "15 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/b309d90c-cf8b-4611-987a-e98f323e131b/"}]}, "investor_view": {"stance": "Weak trend", "stance_tone": "negative", "setup_score": "49", "bottom_line": "The weekly trend is not active. Price is -0.9% below the Trend Line and sits at 77.0% of its 52-week range. The latest completed week returned -0.1%, after a -2.0% four-week move. The latest news-sentiment score is 54/100.", "price_summary": "The weekly trend is not active. Price is -0.9% below the Trend Line and sits at 77.0% of its 52-week range. The latest completed week returned -0.1%, after a -2.0% four-week move.", "volume_summary": "Latest weekly volume is 1.4x the 13-week average. Participation is around or above normal and provides reasonable confirmation.", "momentum_summary": "Performance is -2.0% over four weeks, -6.0% over 12 weeks, and 45.0% over one year. The current trend has remained active for 0 consecutive weeks.", "fundamentals": {"available": false, "summary": "A published fundamentals and factor snapshot is not available for this company.", "rank_scores": [], "groups": []}, "weekly_change": [{"label": "Price follow-through", "value": "-0.1%", "detail": "Latest completed week; four-week move -2.0%.", "tone": "negative", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Indicator stack", "value": "45/52", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "neutral", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "54/100", "detail": "15 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/b309d90c-cf8b-4611-987a-e98f323e131b/"}], "strengths": ["Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is constructive, supporting the smart-money activity read."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Price is below the Trend Line, which keeps downside pressure in focus.", "Activity pressure is negative, which weakens the current setup.", "2 reversal markers appear in the recent smart-money tape."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "evidence": {"weekly_tape": {"label": "Weekly tape", "score": 49.529493134442696, "score_label": "50", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 50/100 tape read.", "detail": "", "metric": "50/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.6}, "indicator_analysis": {"label": "Indicator analysis", "score": 22.208333333333332, "score_label": "22", "tone": "negative", "summary": "Latest 12-week confirmation: trend 3/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.62; 2 reversal markers", "metric": "22/100", "url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 1.45}, "factors": {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, "patient_capital": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "sentiment": {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 15 relevant articles.", "detail": "Ono Pharmaceutical Co., Ltd. 2027 Q1 - Results - Earnings Call Presentation (OTCMKTS:OPHLY) 2026-08-04", "metric": "54/100", "url": "/sentiment/b309d90c-cf8b-4611-987a-e98f323e131b/", "available": true, "weight": 0.95}, "insiders": {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, "earnings": {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}}, "section_nav": [{"id": "overview", "label": "Overview"}, {"id": "price-action", "label": "Price"}, {"id": "volume-demand", "label": "Volume"}, {"id": "momentum", "label": "Momentum"}, {"id": "fundamentals", "label": "Fundamentals"}, {"id": "ownership-flow", "label": "Ownership & Flow"}, {"id": "catalysts-risk", "label": "Catalysts & Risk"}, {"id": "peer-context", "label": "Peer Context"}, {"id": "weekly-data", "label": "Weekly Data"}]}, "chart_url": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/", "api_path": "/terminal/b309d90c-cf8b-4611-987a-e98f323e131b/report/api/"}