{"ticker": {"uuid": "ce563818-80d5-4f19-9b3b-26c92a0bb489", "symbol": "4503", "name": "Astellas Pharma Inc.", "exchange": "JPX", "asset_type": "equity"}, "latest_week": "2026-08-07", "summary": "4503 closed the latest completed week at 2,327 JPY. The 4-week return is 8.6% and the 12-week return is 0.1%. The trend backdrop is inactive, with activity pressure at -0.53.", "description": "Astellas Pharma Inc. manufactures, markets, imports, and exports pharmaceuticals in Japan and internationally. The company offers XTANDI, a treatment for prostate cancer; XOSPATA, a treatment for acute myeloid leukemia; VYLOY, a treatment for gastric cancer; and PADCEV, a treatment for patients with metastatic urothelial cancer. It also provides VEOZAH, a treatment for vasomotor symptoms due to menopause; IZERVAY, a treatment for geographic atrophy secondary to age-related macular degeneration; EVRENZO, a treatment for anemia associated with chronic kidney disease; Betanis/Myrabetriq/BETMIGA, a treatment for overactive bladder; and Prograf, an immunosuppressant. It has a research collaboration with xFOREST Therapeutics to develop RNA-targeted therapies and a partnership agreement with Roche Diabetes Care Japan Co., Ltd. to develop and commercialize an integrated diabetes self-management solution. It offers its products to oncology, ophthalmology, urology, immunology, and women's health areas. The company was formerly known as Yamanouchi Pharmaceutical Co. Ltd. and changed its name to Astellas Pharma Inc. in April 2005. Astellas Pharma Inc. was founded in 1923 and is headquartered in Chuo, Japan.", "setup_signature": "Balanced read", "composite_score": "52", "kpis": [{"label": "Latest Close", "value": "2,327 JPY", "hint": "2026-08-07"}, {"label": "1W Return", "value": "5.7%", "tone": "positive", "hint": "latest completed week"}, {"label": "4W Return", "value": "8.6%", "tone": "positive", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "0.1%", "tone": "positive", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "80.8%", "hint": "42 of 52 weeks active"}, {"label": "Volume Ratio", "value": "1.7x", "hint": "vs 13-week average"}], "classification": {"exchange": "JPX", "country": "JP", "sector": "Healthcare", "industry": "Drug Manufacturers - General", "currency": "JPY", "market_cap": "4090.0B"}, "price": {"trend_line": "2,312 JPY", "fair_value": "1,703 JPY", "vs_trend": "0.6%", "vs_fair_value": "36.6%", "high_52": "2,717 JPY", "low_52": "1,534 JPY", "drawdown": 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11.332645510642632, "volume": "5.2M"}, {"week": "10 Jul", "return": -0.4646840148698885, "return_label": "-0.5%", "return_tone": "negative", "volume_height": 62.0578165353451, "volume": "28.3M"}, {"week": "17 Jul", "return": 0.42016806722689076, "return_label": "0.4%", "return_tone": "positive", "volume_height": 75.27299332111023, "volume": "34.4M"}, {"week": "24 Jul", "return": 0.7205950720595072, "return_label": "0.7%", "return_tone": "positive", "volume_height": 57.966804888360244, "volume": "26.5M"}, {"week": "31 Jul", "return": 1.6385875836602817, "return_label": "1.6%", "return_tone": "positive", "volume_height": 85.42714008144347, "volume": "39.0M"}, {"week": "7 Aug", "return": 5.676657584014532, "return_label": "5.7%", "return_tone": "positive", "volume_height": 82.88197707403732, "volume": "37.8M"}], "insights": [{"label": "Participation", "value": "1.7x", "detail": "Latest volume versus the 13-week average.", "tone": "positive"}, {"label": "Baseline", "value": "22.8M", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "30.4M", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "2.4%", "volatility_52": "4.1%", "downside_weeks": 21, "upside_weeks": 31, "downside_breadth": "40.4%", "average_gain": "3.1%", "average_loss": "-2.4%", "distribution_scale": "11%", "return_callouts": [{"label": "Weeks higher", "value": "15 of 26", "detail": "11 weeks finished lower.", "tone": "positive"}, {"label": "Best week", "value": "+9.6%", "detail": "Week of 27 Mar.", "tone": "positive"}, {"label": "Worst week", "value": "-10.6%", "detail": "Week of 1 May.", "tone": "negative"}, {"label": "Latest week", "value": "+5.7%", "detail": "Week of 7 Aug.", "tone": "positive"}], "buckets": [{"label": "Strong gains", "count": 4, "share": 15.384615384615385, "share_label": "15.4%", "tone": "positive"}, {"label": "Modest gains", "count": 11, "share": 42.30769230769231, "share_label": "42.3%", "tone": "positive"}, {"label": "Flat weeks", "count": 0, "share": 0.0, "share_label": "0.0%", "tone": "neutral"}, {"label": "Modest losses", "count": 8, "share": 30.76923076923077, "share_label": "30.8%", "tone": "negative"}, {"label": "Sharp losses", "count": 3, "share": 11.538461538461538, "share_label": "11.5%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "2.4%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "4.1%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "31/21", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "positive"}, {"label": "Average skew", "value": "3.1% / -2.4%", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Inactive", "tone": "negative"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "0.6%", "tone": "positive"}, {"label": "Volume", "value": "1.7x", "tone": "positive"}], "opportunities": ["Price is above the Trend Line, keeping the weekly tape constructive.", "Price is above Fair Value, showing premium demand versus the model.", "Volume is elevated versus the 13-week average, confirming attention.", "Latest weekly return ranks in the strongest part of its sector group."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Activity pressure is negative, which weakens the current setup.", "Activity pressure is weak, so confirmation is not yet broad enough."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-08-07", "close": "2,327 JPY", "return": null, "return_tone": null, "trend_line": "2,312 JPY", "fair_value": "1,703 JPY", "activity_pressure": "-0.53", "relative_leadership": "-6.62", "volume": "37.8M", "trend_backdrop": null}, {"week": "2026-07-31", "close": "2,202 JPY", "return": null, "return_tone": null, "trend_line": "2,308 JPY", "fair_value": "1,701 JPY", "activity_pressure": "-0.93", "relative_leadership": "-10.01", "volume": "39.0M", "trend_backdrop": null}, {"week": "2026-07-24", "close": "2,166 JPY", "return": null, "return_tone": null, "trend_line": "2,304 JPY", "fair_value": "1,698 JPY", "activity_pressure": "-1.16", "relative_leadership": "-11.93", "volume": "26.5M", "trend_backdrop": null}, {"week": "2026-07-17", "close": "2,151 JPY", "return": null, "return_tone": null, "trend_line": "2,300 JPY", "fair_value": "1,696 JPY", "activity_pressure": "-1.26", "relative_leadership": "-11.95", "volume": "34.4M", "trend_backdrop": null}, {"week": "2026-07-10", "close": "2,142 JPY", "return": null, "return_tone": null, "trend_line": "2,298 JPY", "fair_value": "1,694 JPY", "activity_pressure": "-1.38", "relative_leadership": "-18.03", "volume": "28.3M", "trend_backdrop": null}, {"week": "2026-07-03", "close": "2,152 JPY", "return": null, "return_tone": null, "trend_line": "2,294 JPY", "fair_value": "1,692 JPY", "activity_pressure": "-1.49", "relative_leadership": "-19.17", "volume": "5.2M", "trend_backdrop": null}, {"week": "2026-06-26", "close": "2,145 JPY", "return": null, "return_tone": null, "trend_line": "2,288 JPY", "fair_value": "1,690 JPY", "activity_pressure": "-1.49", "relative_leadership": "-19.11", "volume": "6.2M", "trend_backdrop": null}, {"week": "2026-06-19", "close": "2,146 JPY", "return": null, "return_tone": null, "trend_line": "2,281 JPY", "fair_value": "1,688 JPY", "activity_pressure": "-1.32", "relative_leadership": "-21.34", "volume": "7.2M", "trend_backdrop": null}, {"week": "2026-06-12", "close": "2,140 JPY", "return": null, "return_tone": null, "trend_line": "2,274 JPY", "fair_value": "1,687 JPY", "activity_pressure": "-1.24", "relative_leadership": "-15.48", "volume": "9.0M", "trend_backdrop": null}, {"week": "2026-06-05", "close": "2,161 JPY", "return": null, "return_tone": null, "trend_line": "2,265 JPY", "fair_value": "1,686 JPY", "activity_pressure": "-1.15", "relative_leadership": "-15.50", "volume": "4.2M", "trend_backdrop": null}, {"week": "2026-05-29", "close": "2,283 JPY", "return": null, "return_tone": null, "trend_line": "2,250 JPY", "fair_value": "1,685 JPY", "activity_pressure": "-1.09", "relative_leadership": "-10.52", "volume": "45.7M", "trend_backdrop": null}, {"week": "2026-05-22", "close": "2,270 JPY", "return": null, "return_tone": null, "trend_line": "2,227 JPY", "fair_value": "1,683 JPY", "activity_pressure": "-1.14", "relative_leadership": "-6.94", "volume": "26.0M", "trend_backdrop": null}, {"week": "2026-05-15", "close": "2,324 JPY", "return": null, "return_tone": null, "trend_line": "2,205 JPY", "fair_value": "1,682 JPY", "activity_pressure": "-1.01", "relative_leadership": "-1.70", "volume": "26.9M", "trend_backdrop": null}, {"week": "2026-05-08", "close": "2,300 JPY", "return": null, "return_tone": null, "trend_line": "2,180 JPY", "fair_value": "1,680 JPY", "activity_pressure": "-0.77", "relative_leadership": "-4.61", "volume": "25.0M", "trend_backdrop": null}], "intelligence": {"rating": "Caution", "rating_tone": "negative", "overall_score": "40", "primary_driver": {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 22 relevant articles.", "detail": "Q1 2027 Astellas Pharma Inc Earnings Presentation (Japanese) Transcript", "metric": "54/100", "url": "/sentiment/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 0.95}, "primary_conflict": {"label": "Indicator analysis", "score": 17.187499999999996, "score_label": "17", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.25; No reversal markers", "metric": "17/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.45}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 48.7686365750895, "score_label": "49", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 49/100 tape read.", "detail": "", "metric": "49/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 17.187499999999996, "score_label": "17", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.25; No reversal markers", "metric": "17/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.45}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 22 relevant articles.", "detail": "Q1 2027 Astellas Pharma Inc Earnings Presentation (Japanese) Transcript", "metric": "54/100", "url": "/sentiment/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Indicator analysis", "score": 17.187499999999996, "score_label": "17", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.25; No reversal markers", "metric": "17/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.45}], "conclusion": ["The strongest supporting evidence is sentiment: Weighted news tone is neutral across 22 relevant articles.", "The main constraint is indicator analysis: Latest 12-week confirmation: trend 2/12, activity pressure 0/12, relative leadership 0/12.", "The combined read is defensive, so risk control and evidence of stabilization matter more than headline upside."], "weekly_changes": [{"label": "Price follow-through", "value": "5.7%", "detail": "Latest completed week; four-week move 8.6%.", "tone": "positive", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Indicator stack", "value": "44/45", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "neutral", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "54/100", "detail": "22 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}]}, "investor_view": {"stance": "Mixed setup", "stance_tone": "neutral", "setup_score": "52", "bottom_line": "The weekly trend is not active. Price is 0.6% above the Trend Line and sits at 67.0% of its 52-week range. The latest completed week returned 5.7%, after a 8.6% four-week move. The latest news-sentiment score is 54/100.", "price_summary": "The weekly trend is not active. Price is 0.6% above the Trend Line and sits at 67.0% of its 52-week range. The latest completed week returned 5.7%, after a 8.6% four-week move.", "volume_summary": "Latest weekly volume is 1.7x the 13-week average. Participation is unusually strong and confirms that the move is attracting attention.", "momentum_summary": "Performance is 8.6% over four weeks, 0.1% over 12 weeks, and 49.8% over one year. The current trend has remained active for 0 consecutive weeks.", "fundamentals": {"available": false, "summary": "A published fundamentals and factor snapshot is not available for this company.", "rank_scores": [], "groups": []}, "weekly_change": [{"label": "Price follow-through", "value": "5.7%", "detail": "Latest completed week; four-week move 8.6%.", "tone": "positive", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Indicator stack", "value": "44/45", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "neutral", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "54/100", "detail": "22 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/ce563818-80d5-4f19-9b3b-26c92a0bb489/"}], "strengths": ["Price is above the Trend Line, keeping the weekly tape constructive.", "Price is above Fair Value, showing premium demand versus the model.", "Volume is elevated versus the 13-week average, confirming attention.", "Latest weekly return ranks in the strongest part of its sector group."], "risks": ["The trend backdrop is inactive, so price action has not confirmed a constructive regime.", "Activity pressure is negative, which weakens the current setup.", "Activity pressure is weak, so confirmation is not yet broad enough."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "evidence": {"weekly_tape": {"label": "Weekly tape", "score": 48.7686365750895, "score_label": "49", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 49/100 tape read.", "detail": "", "metric": "49/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.6}, "indicator_analysis": {"label": "Indicator analysis", "score": 17.187499999999996, "score_label": "17", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 0/12, relative leadership 0/12.", "detail": "Activity pressure 0.25; No reversal markers", "metric": "17/100", "url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 1.45}, "factors": {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, "patient_capital": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "sentiment": {"label": "Sentiment", "score": 54.0, "score_label": "54", "tone": "neutral", "summary": "Weighted news tone is neutral across 22 relevant articles.", "detail": "Q1 2027 Astellas Pharma Inc Earnings Presentation (Japanese) Transcript", "metric": "54/100", "url": "/sentiment/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "available": true, "weight": 0.95}, "insiders": {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, "earnings": {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}}, "section_nav": [{"id": "overview", "label": "Overview"}, {"id": "price-action", "label": "Price"}, {"id": "volume-demand", "label": "Volume"}, {"id": "momentum", "label": "Momentum"}, {"id": "fundamentals", "label": "Fundamentals"}, {"id": "ownership-flow", "label": "Ownership & Flow"}, {"id": "catalysts-risk", "label": "Catalysts & Risk"}, {"id": "peer-context", "label": "Peer Context"}, {"id": "weekly-data", "label": "Weekly Data"}]}, "chart_url": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/", "api_path": "/terminal/ce563818-80d5-4f19-9b3b-26c92a0bb489/report/api/"}