{"ticker": {"uuid": "fe76b9a5-9d69-445d-a49e-e107f61ffc89", "symbol": "VRTX", "name": "Vertex Pharmaceuticals Incorporated", "exchange": "MEX", "asset_type": "equity"}, "latest_week": "2026-07-31", "summary": "VRTX closed the latest completed week at 8,262 MXN. The 4-week return is -5.9% and the 12-week return is 12.7%. The trend backdrop is active, with activity pressure at 0.85.", "description": "Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally. The company offers transformative medicines for people with serious diseases with a focus on specialty markets, such as cystic fibrosis (CF), sickle cell disease (SCD), transfusion dependent beta thalassemia (TDT), and acute pain. It markets TRIKAFTA/KAFTRIO for people with CF with at least one F508del mutation for 2 years of age and older; ALYFTREK for the treatment for people with CF 6 years of age and older; SYMDEKO/SYMKEVI for treatment of patients with CF 6 years of age and older; ORKAMBI for CF patients 1 year or older; and KALYDECO for the treatment of patients with 1 month or older who have CF with ivacaftor. The company also develops CASGEVY for the treatment of SCD and TDT; JOURNAVX for the treatment of acute pain in adults; VX-522, a CFTR mRNA therapeutic designed to treat the underlying cause of CF, which is in Phase 1/2 clinical trial; inaxaplin for the treatment of APOL1-mediated kidney disease, which is in single Phase 2 trial; VX-264 for treating Type 1 Diabetes; VX-670 for the treatment of myotonic dystrophy type 1; and VX-407, a small molecule corrector for the treatment of autosomal dominant polycystic kidney disease. The company sells its products primarily to specialty pharmacy and distributors, wholesalers, retail pharmacies, hospitals, and clinics. Vertex Pharmaceuticals Incorporated was founded in 1989 and is headquartered in Boston, Massachusetts.", "setup_signature": "Balanced read", "composite_score": "46", "kpis": [{"label": "Latest Close", "value": "8,262 MXN", "hint": "2026-07-31"}, {"label": "1W Return", "value": "0.9%", "tone": "positive", "hint": "latest completed week"}, {"label": "4W Return", "value": "-5.9%", "tone": "negative", "hint": "short-term follow-through"}, {"label": "12W Return", "value": "12.7%", "tone": "positive", "hint": "quarterly tape"}, {"label": "Trend Breadth", "value": "23.1%", "hint": "12 of 52 weeks active"}, {"label": "Volume Ratio", "value": "0.0x", "hint": "vs 13-week average"}], "classification": {"exchange": "MEX", "country": "MX", "sector": "Healthcare", "industry": "Biotechnology", "currency": "MXN", "market_cap": "1954.3B"}, "price": {"trend_line": "7,988 MXN", "fair_value": "8,034 MXN", "vs_trend": "3.4%", "vs_fair_value": "2.8%", "high_52": "8,784 MXN", "low_52": "6,800 MXN", 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{"week": "24 Jul", "return": -1.5252992907801455, "return_label": "-1.5%", "return_tone": "negative", "volume_height": 4, "volume": "39"}, {"week": "31 Jul", "return": 0.8531336248777172, "return_label": "0.9%", "return_tone": "positive", "volume_height": 4, "volume": "6"}], "insights": [{"label": "Participation", "value": "0.0x", "detail": "Latest volume versus the 13-week average.", "tone": "neutral"}, {"label": "Baseline", "value": "267", "detail": "13-week average volume.", "tone": "neutral"}, {"label": "One-year base", "value": "637", "detail": "52-week average volume.", "tone": "neutral"}]}, "risk": {"volatility_13": "4.1%", "volatility_52": "4.0%", "downside_weeks": 23, "upside_weeks": 23, "downside_breadth": "44.2%", "average_gain": "2.9%", "average_loss": "-3.0%", "distribution_scale": "12%", "return_callouts": [{"label": "Weeks higher", "value": "13 of 26", "detail": "12 weeks finished lower.", "tone": "positive"}, {"label": "Best week", "value": "+11.2%", "detail": "Week of 26 Jun.", "tone": "positive"}, {"label": "Worst week", "value": "-4.4%", "detail": "Week of 10 Apr.", "tone": "negative"}, {"label": "Latest week", "value": "+0.9%", "detail": "Week of 31 Jul.", "tone": "positive"}], "buckets": [{"label": "Strong gains", "count": 3, "share": 11.538461538461538, "share_label": "11.5%", "tone": "positive"}, {"label": "Modest gains", "count": 10, "share": 38.46153846153847, "share_label": "38.5%", "tone": "positive"}, {"label": "Flat weeks", "count": 1, "share": 3.8461538461538463, "share_label": "3.8%", "tone": "neutral"}, {"label": "Modest losses", "count": 11, "share": 42.30769230769231, "share_label": "42.3%", "tone": "negative"}, {"label": "Sharp losses", "count": 1, "share": 3.8461538461538463, "share_label": "3.8%", "tone": "negative"}], "insights": [{"label": "Recent vol", "value": "4.1%", "detail": "13-week weekly-return volatility.", "tone": "neutral"}, {"label": "Base vol", "value": "4.0%", "detail": "52-week weekly-return volatility.", "tone": "neutral"}, {"label": "Up/down split", "value": "23/23", "detail": "Count of positive and negative weeks in the 52-week window.", "tone": "neutral"}, {"label": "Average skew", "value": "2.9% / -3.0%", "detail": "Average positive week versus average negative week.", "tone": "neutral"}]}, "signals": [{"label": "Trend backdrop", "value": "Active", "tone": "positive"}, {"label": "Activity pressure", "value": "No fresh buy", "tone": "neutral"}, {"label": "Price vs Trend", "value": "3.4%", "tone": "positive"}, {"label": "Volume", "value": "0.0x", "tone": "neutral"}], "opportunities": ["The trend backdrop is active with a 2-week active streak.", "Price is above the Trend Line, keeping the weekly tape constructive.", "Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is positive on the latest completed week."], "risks": ["Activity pressure is weak, so confirmation is not yet broad enough."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "recent_rows": [{"week": "2026-07-31", "close": "8,262 MXN", "return": null, "return_tone": null, "trend_line": "7,988 MXN", "fair_value": "8,034 MXN", "activity_pressure": "0.85", "relative_leadership": "2.64", "volume": "6", "trend_backdrop": null}, {"week": "2026-07-24", "close": "8,192 MXN", "return": null, "return_tone": null, "trend_line": "7,987 MXN", "fair_value": "8,019 MXN", "activity_pressure": "0.99", "relative_leadership": "2.12", "volume": "39", "trend_backdrop": null}, {"week": "2026-07-17", "close": "8,319 MXN", "return": null, "return_tone": null, "trend_line": "7,989 MXN", "fair_value": "8,006 MXN", "activity_pressure": "1.08", "relative_leadership": "2.82", "volume": "87", "trend_backdrop": null}, {"week": "2026-07-10", "close": "8,530 MXN", "return": null, "return_tone": null, "trend_line": "7,976 MXN", "fair_value": "7,992 MXN", "activity_pressure": "0.78", "relative_leadership": "5.11", "volume": "2.0K", "trend_backdrop": null}, {"week": "2026-07-03", "close": "8,784 MXN", "return": null, "return_tone": null, "trend_line": "7,956 MXN", "fair_value": "7,975 MXN", "activity_pressure": "0.20", "relative_leadership": "6.86", "volume": "20", "trend_backdrop": null}, {"week": "2026-06-26", "close": "8,670 MXN", "return": null, "return_tone": null, "trend_line": "7,939 MXN", "fair_value": "7,956 MXN", "activity_pressure": "-0.39", "relative_leadership": "5.01", "volume": "114", "trend_backdrop": null}, {"week": "2026-06-19", "close": "7,795 MXN", "return": null, "return_tone": null, "trend_line": "7,917 MXN", "fair_value": "7,939 MXN", "activity_pressure": "-0.84", "relative_leadership": "-6.51", "volume": "0", "trend_backdrop": null}, {"week": "2026-06-12", "close": "7,592 MXN", "return": null, "return_tone": null, "trend_line": "7,925 MXN", "fair_value": "7,927 MXN", "activity_pressure": "-0.95", "relative_leadership": "-9.75", "volume": "0", "trend_backdrop": null}, {"week": "2026-06-05", "close": "7,426 MXN", "return": null, "return_tone": null, "trend_line": "7,942 MXN", "fair_value": "7,917 MXN", "activity_pressure": "-0.94", "relative_leadership": "-9.83", "volume": "0", "trend_backdrop": null}, {"week": "2026-05-29", "close": "7,700 MXN", "return": null, "return_tone": null, "trend_line": "7,953 MXN", "fair_value": "7,905 MXN", "activity_pressure": "-0.98", "relative_leadership": "-10.37", "volume": "53", "trend_backdrop": null}, {"week": "2026-05-22", "close": "7,535 MXN", "return": null, "return_tone": null, "trend_line": "7,956 MXN", "fair_value": "7,892 MXN", "activity_pressure": "-1.08", "relative_leadership": "-12.50", "volume": "1.1K", "trend_backdrop": null}, {"week": "2026-05-15", "close": "7,770 MXN", "return": null, "return_tone": null, "trend_line": "7,965 MXN", "fair_value": "7,881 MXN", "activity_pressure": "-1.14", "relative_leadership": "-9.75", "volume": "25", "trend_backdrop": null}, {"week": "2026-05-08", "close": "7,333 MXN", "return": null, "return_tone": null, "trend_line": "7,957 MXN", "fair_value": "7,870 MXN", "activity_pressure": "-1.13", "relative_leadership": "-17.52", "volume": "47", "trend_backdrop": null}, {"week": "2026-05-01", "close": "7,501 MXN", "return": null, "return_tone": null, "trend_line": "7,967 MXN", "fair_value": "7,862 MXN", "activity_pressure": "-1.05", "relative_leadership": "-13.70", "volume": "119", "trend_backdrop": null}], "intelligence": {"rating": "Neutral", "rating_tone": "neutral", "overall_score": "45", "primary_driver": {"label": "Sentiment", "score": 55.0, "score_label": "55", "tone": "neutral", "summary": "Weighted news tone is neutral across 33 relevant articles.", "detail": "Is Vertex Pharmaceuticals (VRTX) Cheap On Its AbCellera Collaboration News?", "metric": "55/100", "url": "/sentiment/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 0.95}, "primary_conflict": {"label": "Indicator analysis", "score": 37.11805555555555, "score_label": "37", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 5/12, relative leadership 6/12.", "detail": "Activity pressure 0.35; No reversal markers", "metric": "37/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.45}, "options_tone": "neutral", "options": null, "evidence": [{"label": "Weekly tape", "score": 45.37982310838729, "score_label": "45", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 45/100 tape read.", "detail": "", "metric": "45/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.6}, {"label": "Indicator analysis", "score": 37.11805555555555, "score_label": "37", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 5/12, relative leadership 6/12.", "detail": "Activity pressure 0.35; No reversal markers", "metric": "37/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.45}, {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, {"label": "Sentiment", "score": 55.0, "score_label": "55", "tone": "neutral", "summary": "Weighted news tone is neutral across 33 relevant articles.", "detail": "Is Vertex Pharmaceuticals (VRTX) Cheap On Its AbCellera Collaboration News?", "metric": "55/100", "url": "/sentiment/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 0.95}, {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}], "positives": [], "negatives": [{"label": "Indicator analysis", "score": 37.11805555555555, "score_label": "37", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 5/12, relative leadership 6/12.", "detail": "Activity pressure 0.35; No reversal markers", "metric": "37/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.45}], "conclusion": ["The strongest supporting evidence is sentiment: Weighted news tone is neutral across 33 relevant articles.", "The main constraint is indicator analysis: Latest 12-week confirmation: trend 2/12, activity pressure 5/12, relative leadership 6/12.", "The combined read is balanced, making the next change in trend, sentiment, or options pressure especially important."], "weekly_changes": [{"label": "Price follow-through", "value": "0.9%", "detail": "Latest completed week; four-week move -5.9%.", "tone": "positive", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Indicator stack", "value": "20/91", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "55/100", "detail": "33 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}]}, "investor_view": {"stance": "Mixed setup", "stance_tone": "neutral", "setup_score": "46", "bottom_line": "The weekly trend is active. Price is 3.4% above the Trend Line and sits at 73.7% of its 52-week range. The latest completed week returned 0.9%, after a -5.9% four-week move. The latest news-sentiment score is 55/100. Near-term considerations: volume confirmation is below normal.", "price_summary": "The weekly trend is active. Price is 3.4% above the Trend Line and sits at 73.7% of its 52-week range. The latest completed week returned 0.9%, after a -5.9% four-week move.", "volume_summary": "Latest weekly volume is 0.0x the 13-week average. Participation is below its recent norm, so price strength is not receiving full volume confirmation.", "momentum_summary": "Performance is -5.9% over four weeks, 12.7% over 12 weeks, and -5.7% over one year. The current trend has remained active for 2 consecutive weeks.", "fundamentals": {"available": false, "summary": "A published fundamentals and factor snapshot is not available for this company.", "rank_scores": [], "groups": []}, "weekly_change": [{"label": "Price follow-through", "value": "0.9%", "detail": "Latest completed week; four-week move -5.9%.", "tone": "positive", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Indicator stack", "value": "20/91", "detail": "Trend and activity pressure are weighted against the latest 12-week confirmation window.", "tone": "negative", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Trend backdrop", "value": "Active", "detail": "The trend backdrop defines the current weekly regime.", "tone": "positive", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}, {"label": "Patient Capital", "value": "Quiet", "detail": "Activity-pressure buy-signal status for institutional accumulation timing.", "tone": "neutral", "url": "/patient-capital/"}, {"label": "News sentiment", "value": "55/100", "detail": "33 relevant articles in the latest sentiment read.", "tone": "neutral", "url": "/sentiment/fe76b9a5-9d69-445d-a49e-e107f61ffc89/"}], "strengths": ["The trend backdrop is active with a 2-week active streak.", "Price is above the Trend Line, keeping the weekly tape constructive.", "Price is above Fair Value, showing premium demand versus the model.", "Activity pressure is positive on the latest completed week."], "risks": ["Activity pressure is weak, so confirmation is not yet broad enough."], "watch_points": ["Trend Line remains the key weekly regime level.", "Activity pressure is the gauge to monitor for confirmation or fade.", "A volume ratio above 1.5x would show stronger participation in the next move."], "evidence": {"weekly_tape": {"label": "Weekly tape", "score": 45.37982310838729, "score_label": "45", "tone": "neutral", "summary": "Trend, activity pressure, participation, and risk combine to a 45/100 tape read.", "detail": "", "metric": "45/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.6}, "indicator_analysis": {"label": "Indicator analysis", "score": 37.11805555555555, "score_label": "37", "tone": "negative", "summary": "Latest 12-week confirmation: trend 2/12, activity pressure 5/12, relative leadership 6/12.", "detail": "Activity pressure 0.35; No reversal markers", "metric": "37/100", "url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 1.45}, "factors": {"label": "Factors", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No published factor snapshot is available yet.", "detail": "", "metric": "50/100", "url": "/factors/", "available": false, "weight": 0}, "patient_capital": {"label": "Patient Capital", "score": 48.0, "score_label": "48", "tone": "neutral", "summary": "Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.", "detail": "No recent buy signal", "metric": "Quiet", "url": "/patient-capital/", "available": true, "weight": 1}, "sentiment": {"label": "Sentiment", "score": 55.0, "score_label": "55", "tone": "neutral", "summary": "Weighted news tone is neutral across 33 relevant articles.", "detail": "Is Vertex Pharmaceuticals (VRTX) Cheap On Its AbCellera Collaboration News?", "metric": "55/100", "url": "/sentiment/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "available": true, "weight": 0.95}, "insiders": {"label": "Insiders", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No recent insider transaction evidence is stored.", "detail": "", "metric": "50/100", "url": "/insider-activity/", "available": false, "weight": 0}, "earnings": {"label": "Earnings", "score": 50.0, "score_label": "50", "tone": "neutral", "summary": "No stored earnings event is currently attached to this ticker.", "detail": "", "metric": "50/100", "url": "/earnings-calendar/", "available": false, "weight": 0}}, "section_nav": [{"id": "overview", "label": "Overview"}, {"id": "price-action", "label": "Price"}, {"id": "volume-demand", "label": "Volume"}, {"id": "momentum", "label": "Momentum"}, {"id": "fundamentals", "label": "Fundamentals"}, {"id": "ownership-flow", "label": "Ownership & Flow"}, {"id": "catalysts-risk", "label": "Catalysts & Risk"}, {"id": "peer-context", "label": "Peer Context"}, {"id": "weekly-data", "label": "Weekly Data"}]}, "chart_url": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/", "api_path": "/terminal/fe76b9a5-9d69-445d-a49e-e107f61ffc89/report/api/"}