Weekly Report - Taysha Gene Therapies, Inc. (TSHA)

Entity & Brand

Company	Taysha Gene Therapies, Inc.
Ticker	TSHA
Exchange	NASDAQ
Weeks Used	8

Signals Snapshot

8-week window ?

No signals in this window.

How to read this section

Left column describes the week the signal was generated (historical context). Right column shows performance and posture since that signal to the present. MFE ? and MAE ? quantify upside capture vs downside risk after the signal.

Price Overview

Tiles ?

Metric	Signal	Value	Notes
Price Window	Positive	7.60% over 8w	Endpoint return across the selected window.
Volume Trend	Positive	Rising	Slope of weekly volume across the window.
Vs 8w High	Negative	-15.77%	Distance to the prior-window high (latest week excluded).
MA Stack	Positive	Constructive	Short > Intermediate > Long is constructive; the reverse is weak.

Trend Overview

Metric	Signal	Value
Gauge Reading	Neutral	80.3/100
Direction	Negative	Falling
Acceleration	Negative	decelerating
Gauge Volatility	Neutral	Low
Trend State	Positive	Uptrend at Risk

Trend State: Uptrend at Risk — gauge 80.3/100 — 8w slope -0.40; ST slope -1.27 pts/wk — vol low ?

Distribution at highs 3/5 (60.0%) High-regime breakdown (from ≥0.80)

Weekly Price Action

8 weeks ?

Week ending	Open	High	Low	Close	Change %	Volume (MA) Trend
Fri, 19 Sep 2025	2.99	3.03	2.80	2.83	-5.35%
Fri, 12 Sep 2025	3.24	3.27	3.04	3.07	-5.25%
Fri, 5 Sep 2025	3.30	3.40	3.21	3.36	1.82%
Fri, 29 Aug 2025	2.84	2.92	2.79	2.92	2.82%
Fri, 22 Aug 2025	2.90	3.09	2.81	2.83	-2.41%
Fri, 15 Aug 2025	2.96	2.99	2.85	2.94	-0.68%
Fri, 8 Aug 2025	2.81	2.85	2.70	2.72	-3.20%
Fri, 1 Aug 2025	2.69	2.78	2.62	2.63	-2.23%	—

Price Narrative

Stands Out	No highlights available.
What to Watch	No watch items available.

Trend Narrative

Stands Out	Trend focus for week ending Fri, 19 Sep 2025. Gauge: 80.3/100; slope -0.40 pts/wk; short-term -1.27 pts/wk; decelerating. Gauge volatility: low. Momentum drawdown from 8w peak: 4.5 pts. Recent breakdown from ≥80. High-regime (0.80–1.00) downticks 3/5 (60.0%), bias: Distributing.
What to Watch	How to read this — Gauge is elevated but momentum is rolling over; topping risk is rising. Notable breakdown from ≥0.80 weakens trend quality.

All Price Analysis

Complete dump of monthly_analysis.series & monthly_analysis.diagnostics

Series
Close Price	Change Pct: 7.604562737642592, Slope: 0.05357142857142857
Change Percent	Vol: 2.8000982125632663, Slope: -0.23047619047619047
Volume	Slope: 1269015.4761904762, Z Last: 1.7844277119827439
Deviation From Baseline	Last: 0.42464, Z Last: 0.5870675439286803, Slope: 0.1977361904761905
Diagnostics
Volume Trend	rising
Close Vs Recent High Pct	-15.773809523809518
Conv Div	convergence
Momentum Trend	weakening
Last Trend Label	Bullish
Close Vs Recent Low Pct	7.604562737642592
Ma Stack	bull
Cross 4 8	none
Price Vs Ma	mixed
Baseline Deviation	0.42464
Baseline Dir	widening

What does it mean?

8-week price move: 7.60%. Weekly return volatility: 2.80%. Close is 15.77% below the prior-window 8-week high. and 7.60% above the prior-window 8-week low. Volume trend: rising. Latest week’s volume is 1.78σ from its 8-week average. Price/volume correlation (returns vs volume): -0.43. Price/volume correlation (returns vs volume change): -0.55. 26-week move: 124.60%. 52-week move: 40.10%. Price sits 0.42% above its medium-term baseline, and the distance is widening. Moving-average stack is constructive (short above intermediate above long).
How to read this — Price slope is upward, indicating persistent buying over the window. Volume and price are moving in the same direction — a constructive confirmation. Returns are negatively correlated with volume — strength may come on lighter activity. Constructive MA stack supports the up-drift; pullbacks may find support at the 8–13 week region.
Up-slope supports buying interest; pullbacks may be contained if activity stays firm.

All Trend Analysis

Complete dump of trend_analysis.series & trend_analysis.diagnostics

Series
Trend Pos	Avg: 82.11725, Med: 82.0335, Rng: (79.453, 84.79299999999999), Vol: 2.0325892200589855, Slope: -0.40414285714285586, Last: 80.312
Diagnostics
Last Pos	80.312
Vol Band	low
Acceleration Label	Decelerating
Last Label	Bullish
State Label	Uptrend at Risk
Slope 8W	-0.40414285714285586
Slope Short	-1.2721000000000018
Accel Value	-0.4113571428571439
Drawdown From Peak Pts	4.4809999999999945
Time In Bull	8
Time In Bear	0
Time In Mid	0
High Breakdown Recent	True
Midline Failure Recent	False
Bear Control Recent	False
Recovery Mid Recent	False
Recovery Bull Recent	False
Acc Upticks	0
Acc Opportunities	0
Acc Rate	None
Acc Longest Streak	0
Dist Downticks	3
Dist Opportunities	5
Dist Rate	0.6
Dist Longest Streak	1
Low Regime Bias	Mixed/None
High Regime Bias	Distributing

What does it mean?

Trend focus for week ending Fri, 19 Sep 2025. Gauge: 80.3/100; slope -0.40 pts/wk; short-term -1.27 pts/wk; decelerating. Gauge volatility: low. Momentum drawdown from 8w peak: 4.5 pts. Recent breakdown from ≥80. High-regime (0.80–1.00) downticks 3/5 (60.0%), bias: Distributing.
How to read this — Gauge is elevated but momentum is rolling over; topping risk is rising. Notable breakdown from ≥0.80 weakens trend quality.
Stay alert: protect gains or seek confirmation before adding risk.

Final Conclusion

Verdict	Negative
Stars	★★☆☆☆
Summary	Price window: 7. Trend: Uptrend at Risk; gauge 80. In combination, liquidity confirms the move.
Strengths	Constructive moving-average stack Liquidity confirms the price trend
Watch-outs	High-level but rolling over (topping risk) Momentum is weak/falling Price is not above key averages Sellers active at elevated levels (distribution)

Disclaimer. This report is provided for educational and informational purposes only and does not constitute investment advice, an offer, or a solicitation to buy or sell any security. Past performance is not indicative of future results. Markets involve risk, including possible loss of principal. Always perform your own research and consider consulting a qualified financial professional before making investment decisions.