UPB - NASDAQ
Weekly Report for Upstream Bio, Inc.
Entity & Brand
?Signals Snapshot
8-week window
?
Threshold Breach (Sell)
Mon, 1 Sep 2025
Source:
market_cycle
Signal close
?:
19.97
At the signal (week of Mon, 1 Sep 2025)
- Week change: +18.41%
- Closed near the weekly high (strong finish).
- Close sits at/above the short-term trend.
- Above the intermediate trend backdrop.
- Participation improving (volume trend rising).
- Since signal (perf): +17.98% over 2w; MFE +17.98% (0w), MAE -0.00% (2w).
Since the signal (to present)
MFE
?
MAE
?
Elapsed
2w
Current return
-17.98%
MFE
0.00%
(0w)
MAE
-17.98%
(2w)
ST: Below
MT: Below
Summary
At the threshold breach (sell) week
(Mon, 1 Sep 2025) you saw the bullet points above.
Since then,
price is
-17.98%
over 2 weeks.
Peak move [MFE]:
0.00%
(0w);
worst dip [MAE]:
-17.98%
(2w).
Current situation since SELL
Elapsed: 2w
Close then → now:
19.97 → 16.38
Δ:
-3.59
(-17.98%)
Now vs trend:
ST Below,
MT Below
Weekly snapshots
| Date | Close | % from Signal | ST | MT | Wk % |
|---|---|---|---|---|---|
| Mon, 1 Sep 2025 | 19.97 | 0.00% | Above | Above | 18.41% |
| Mon, 8 Sep 2025 | 17.57 | -12.02% | Below | Near | -12.50% |
| Mon, 15 Sep 2025 | 16.38 | -17.98% | Below | Below | -8.13% |
How to read this section
Left column describes the week the signal was generated (historical context).
Right column shows performance and posture since that signal to the present.
MFE
?
and MAE
?
quantify upside capture vs downside risk after the signal.
Price Overview
Tiles| Metric | Signal | Value | Notes | |
|---|---|---|---|---|
| Price Window | Positive | 5.41% over 8w | Endpoint return across the selected window. | |
| Return Volatility | Negative | 11.56% | Std dev of weekly returns — low is steadier, high is whipsaw-prone. | |
| Volume Trend | Positive | Rising | Slope of weekly volume across the window. | |
| Vs 8w High | Negative | -17.98% | Distance to the prior-window high (latest week excluded). | |
| MA Stack | Positive | Constructive | Short > Intermediate > Long is constructive; the reverse is weak. |
Trend Overview
| Metric | Signal | Value | Notes | |
|---|---|---|---|---|
| Gauge Reading | Neutral | 75.8/100 | ||
| Direction | Positive | Rising | ||
| Acceleration | Negative | decelerating | ||
| Gauge Volatility | Neutral | High | ||
| Trend State | Positive | Range / Neutral |
Trend State:
Range / Neutral — gauge 75.8/100 — 8w slope 7.37; ST slope 6.54 pts/wk — vol high
Weekly Price Action
8 weeks| Week ending | Open | High | Low | Close | Change % | Volume (MA) Trend |
|---|---|---|---|---|---|---|
| Mon, 15 Sep 2025 | 17.83 | 18.00 | 15.55 | 16.38 | -8.13% | |
| Mon, 8 Sep 2025 | 20.08 | 20.32 | 17.02 | 17.57 | -12.50% | |
| Mon, 1 Sep 2025 | 16.87 | 21.03 | 16.66 | 19.97 | 18.41% | |
| Mon, 25 Aug 2025 | 17.60 | 17.78 | 16.37 | 17.13 | -2.67% | |
| Mon, 18 Aug 2025 | 18.93 | 19.37 | 16.02 | 17.63 | -6.87% | |
| Mon, 11 Aug 2025 | 16.00 | 19.28 | 15.64 | 18.93 | 18.31% | |
| Mon, 4 Aug 2025 | 15.59 | 17.57 | 15.04 | 16.00 | 2.63% | |
| Mon, 28 Jul 2025 | 13.73 | 16.15 | 12.95 | 15.54 | 13.18% | — |
Price Narrative
| Stands Out | No highlights available. |
|---|---|
| What to Watch | No watch items available. |
Trend Narrative
| Stands Out | Trend focus for week ending Mon, 15 Sep 2025. Gauge: 75.8/100; slope 7.37 pts/wk; short-term 6.54 pts/wk; decelerating. Gauge volatility: high. Momentum drawdown from 8w peak: 0.0 pts. Recovery attempt (crossed up to ≥60). |
|---|---|
| What to Watch | How to read this — Range-bound conditions; conviction is limited until a break or acceleration emerges. |
All Price Analysis
Complete dump ofmonthly_analysis.series & monthly_analysis.diagnostics
| Series | |
|---|---|
| Close Price | Change Pct: 5.405405405405405, Slope: 0.19464285714285712 |
| Change Percent | Vol: 11.559573954086716, Slope: -2.6228571428571428 |
| Volume | Slope: 317473.1904761905, Z Last: 1.9950936825825811 |
| Deviation From Baseline | Last: 0.16448, Z Last: -1.0082687153711516, Slope: 0.006454999999999999 |
| Diagnostics | |
| Volume Trend | rising |
| Close Vs Recent High Pct | -17.97696544817226 |
| Conv Div | convergence |
| Momentum Trend | improving |
| Last Trend Label | Bullish |
| Close Vs Recent Low Pct | 5.405405405405405 |
| Ma Stack | bull |
| Cross 4 8 | none |
| Price Vs Ma | mixed |
| Baseline Deviation | 0.16448 |
| Baseline Dir | widening |
What does it mean?
- 8-week price move: 5.41%. Weekly return volatility: 11.56%. Close is 17.98% below the prior-window 8-week high. and 5.41% above the prior-window 8-week low. Volume trend: rising. Latest week’s volume is 2.00σ from its 8-week average. Price/volume correlation (returns vs volume): 0.23. Price/volume correlation (returns vs volume change): 0.49. 26-week move: 138.43%. 52-week move: -19.11%. Price sits 0.16% above its medium-term baseline, and the distance is widening. Moving-average stack is constructive (short above intermediate above long).
- How to read this — Price slope is upward, indicating persistent buying over the window. Elevated weekly volatility increases whipsaw risk. Volume and price are moving in the same direction — a constructive confirmation. Constructive MA stack supports the up-drift; pullbacks may find support at the 8–13 week region.
- Up-slope supports buying interest; pullbacks may be contained if activity stays firm.
All Trend Analysis
Complete dump oftrend_analysis.series & trend_analysis.diagnostics
| Series | |
|---|---|
| Trend Pos | Avg: 53.067375, Med: 54.2975, Rng: (28.552, 75.766), Vol: 17.115189335335295, Slope: 7.3737738095238115, Last: 75.766 |
| Diagnostics | |
| Last Pos | 75.766 |
| Vol Band | high |
| Acceleration Label | Decelerating |
| Last Label | Bullish |
| State Label | Range / Neutral |
| Slope 8W | 7.3737738095238115 |
| Slope Short | 6.543900000000003 |
| Accel Value | -0.25953571428571337 |
| Drawdown From Peak Pts | 0.0 |
| Time In Bull | 3 |
| Time In Bear | 3 |
| Time In Mid | 2 |
| High Breakdown Recent | False |
| Midline Failure Recent | False |
| Bear Control Recent | False |
| Recovery Mid Recent | False |
| Recovery Bull Recent | True |
| Acc Upticks | 0 |
| Acc Opportunities | 0 |
| Acc Rate | None |
| Acc Longest Streak | 0 |
| Dist Downticks | 0 |
| Dist Opportunities | 0 |
| Dist Rate | None |
| Dist Longest Streak | 0 |
| Low Regime Bias | Mixed/None |
| High Regime Bias | Mixed/None |
What does it mean?
- Trend focus for week ending Mon, 15 Sep 2025. Gauge: 75.8/100; slope 7.37 pts/wk; short-term 6.54 pts/wk; decelerating. Gauge volatility: high. Momentum drawdown from 8w peak: 0.0 pts. Recovery attempt (crossed up to ≥60).
- How to read this — Range-bound conditions; conviction is limited until a break or acceleration emerges.
- Wait for a directional break or improving acceleration.
Final Conclusion
| Verdict | Neutral |
|---|---|
| Stars | ★★★☆☆ |
| Summary | Price window: 5. Trend: Range / Neutral; gauge 75. In combination, liquidity confirms the move. |
| Strengths |
|
| Watch-outs |
|
Disclaimer. This report is provided for educational and informational purposes only and does not constitute investment advice, an offer, or a solicitation to buy or sell any security. Past performance is not indicative of future results. Markets involve risk, including possible loss of principal. Always perform your own research and consider consulting a qualified financial professional before making investment decisions.