TLSA NASDAQ Week ended 31 Jul 2026

Weekly Investor Report

Tiziana Life Sciences Ltd · Healthcare · Biotechnology

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Latest close 1.03 USD
15.4% latest week
Weekly setup

Weak trend

The weekly trend is not active. Price is -21.1% below the Trend Line and sits at 9.8% of its 52-week range. The latest completed week returned 15.4%, after a -21.4% four-week move. The latest factor snapshot indicates quality is middle-of-the-pack; growth is moderate; valuation is neither clearly cheap nor expensive. Options positioning is bullish with 40/100 conviction, while the latest news-sentiment score is 55/100. Near-term considerations: volume confirmation is below normal; earnings are due in 1d.

Setup score 13 out of 100
Latest Close 1.03 USD 31 Jul 2026
1W Return 15.4% latest completed week
4W Return -21.4% short-term follow-through
12W Return -34.8% quarterly tape
Trend Breadth 32.7% 17 of 52 weeks active
Volume Ratio 0.7x vs 13-week average
What is working
  • No strong opportunity cluster is confirmed yet; monitor trend and activity pressure.
What could go wrong
  • The trend backdrop is inactive, so price action has not confirmed a constructive regime.
  • Price is below the Trend Line, which keeps downside pressure in focus.
  • Price is below Fair Value, so the market is still discounting the latest tape.
  • Activity pressure is negative, which weakens the current setup.
What to watch next
  • Trend Line remains the key weekly regime level.
  • Activity pressure is the gauge to monitor for confirmation or fade.
  • A volume ratio above 1.5x would show stronger participation in the next move.
Price follow-through 15.4% Latest completed week; four-week move -21.4%. Indicator stack 18/0 Trend and activity pressure are weighted against the latest 12-week confirmation window. Trend backdrop Active The trend backdrop defines the current weekly regime. Patient Capital Quiet Activity-pressure buy-signal status for institutional accumulation timing. Next-Week Expectancy Negative 44.78% Historical one-week expectancy contributes to the evidence score when direction is confirmed. Options pressure Bullish 40/100 conviction; expected move 165.0%. News sentiment 55/100 52 relevant articles in the latest sentiment read. Event risk 1d Next report is scheduled for 07 Aug 2026; event risk rises as the date approaches.
01 · Price action

Where price is—and whether the trend supports it

The weekly trend is not active. Price is -21.1% below the Trend Line and sits at 9.8% of its 52-week range. The latest completed week returned 15.4%, after a -21.4% four-week move.

Study the full chart

52-week price path

Price vs Trend Line and Fair Value
Price Trend Line Fair Value
02 · Volume and demand

Is real participation confirming the move?

Latest weekly volume is 0.7x the 13-week average. Participation is below its recent norm, so price strength is not receiving full volume confirmation.

26-week volume confirmation

Bar height shows volume; colour shows the weekly price direction
6 Feb 13 Feb 20 Feb 27 Feb 6 Mar 13 Mar 20 Mar 27 Mar 3 Apr 10 Apr 17 Apr 24 Apr 1 May 8 May 15 May 22 May 29 May 5 Jun 12 Jun 19 Jun 26 Jun 3 Jul 10 Jul 17 Jul 24 Jul 31 Jul
Up week Down week
Demand beneath price

Activity pressure and institutional-style signals

These indicators assess whether participation is improving beneath the headline price move. They are supporting evidence, not proof of institutional buying.

Activity pressure path

Latest 0.0812-week average 0.10

12-week confirmation

Trend active0/12Active trend-backdrop weeks in the latest 12-week window.
Positive pressure8/12Weeks with constructive activity pressure in the latest 12-week window.
Positive leadership0/12Weeks with positive relative leadership in the latest 12-week window.
Activity pressure0.08Current proprietary activity-pressure read.
Buy signals0Accumulation signal count in the latest 12 weeks.
Reversal markers0No reversal markers

No recent accumulation markers. No reversal markers.

03 · Momentum and leadership

Is performance persistent—and is the stock leading?

Performance is -21.4% over four weeks, -34.8% over 12 weeks, and -56.7% over one year. The current trend has remained active for 0 consecutive weeks.

Performance by holding period

1W15.4%
4W-21.4%
12W-34.8%
26W-31.8%
52W-56.7%
Active trend streak0 weeks
Active weeks in one year17
Trend breadth32.7%

Activity pressure vs relative leadership

Activity pressureRelative leadership
Pressure-0.45Latest activity-pressure read.
Pressure change-1197.0%Four-week change in activity pressure.
Leadership-38.94Latest relative-leadership reading.
RS change-34.6%Four-week change in relative leadership.
04 · Fundamentals and valuation

What investors are paying for—and the quality behind it

The latest factor snapshot indicates quality is middle-of-the-pack; growth is moderate; valuation is neither clearly cheap nor expensive.

Open full factor analysis
Factor week 02 Aug 2026 Financial statements through 31 Mar 2026 Field coverage 64% Model confidence 60%

Relative factor standing

Higher display scores are better. Each score is converted from the underlying universe rank, where rank 1 is best.

Overall factor strength34/100Blend of value, momentum, and quality. Underlying universe rank 67; rank 1 is best.
Value42/100Relative valuation strength. Underlying universe rank 59; rank 1 is best.
Quality40/100Profitability and accounting quality. Underlying universe rank 61; rank 1 is best.
Momentum43/100Medium-term price momentum. Underlying universe rank 58; rank 1 is best.
Growth42/100Revenue and earnings growth. Underlying universe rank 59; rank 1 is best.
How to read this

Quality and valuation are separate questions

A strong company can still carry a demanding valuation. This report shows profitability, growth, balance-sheet strength, and the price paid for those characteristics separately.

Valuation

How much investors are paying for earnings, sales, and cash flow.

P/E
-
Price divided by trailing earnings.
Price / sales
-
Market value relative to trailing revenue.
EV / EBITDA
-
Enterprise value relative to operating cash earnings.
Free-cash-flow yield
-10.1%
Free cash flow as a share of enterprise value.

Business quality

Margins and the return generated on invested capital.

Gross margin
-
Gross profit retained from each unit of revenue.
Operating margin
-
Operating profit retained from revenue.
Free-cash-flow margin
-
Free cash flow generated from revenue.
Return on invested capital
-
Operating return generated on invested capital.

Growth and financial strength

Recent business growth and accounting strength.

Revenue growth
-
Latest one-year revenue growth.
EPS growth
-
Latest one-year earnings-per-share growth.
Free-cash-flow growth
-
Latest one-year free-cash-flow growth.
Piotroski F-score
1/9
Nine-point accounting-strength checklist.

Shareholder return and balance sheet

Cash returned to owners and financial leverage.

Dividend yield
-
Cash dividends relative to market value.
Buyback yield
-7.7%
Net share repurchases relative to market value.
Shareholder yield
-7.7%
Dividend yield plus net buyback yield.
Net debt / EBITDA
0.2x
Balance-sheet debt relative to operating cash earnings.
05 · Ownership, options, and sentiment

What other market participants are doing

Options, insider transactions, market sentiment, and activity-pressure signals can confirm or challenge the price story. None should be used alone.

Options positioningBullish

TLSA shows bullish options pressure with a 40/100 conviction score, put-call volume ratio of 0.27, expected move of 165.0%, and Sharemaestro trend signal inactive.

Conviction40/100
Expected move165.0%
Put/call volume0.27
Pressure67
Speculation11
Volatility96
Trend agreement0
Open options detail
Insider activity-

No recent insider transactions are stored for this company.

News sentiment55/100

Weighted news tone is neutral across 52 relevant articles.

12 positive · 38 neutral · 2 negative
Patient CapitalQuiet

Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.

No recent buy signal
06 · Catalysts and risk

What can move the shares—and how volatile the path has been

Event timing, options-implied movement, drawdown, and weekly return distribution frame the risk around the current setup.

Next earnings1dNext report is scheduled for 07 Aug 2026; event risk rises as the date approaches.
Options expected move165.0%Nearest-chain priced movement where available.
52-week drawdown-59.3%Distance below the 52-week high.
13-week volatility11.5%Standard deviation of weekly returns.

Weekly gains and losses

Latest 26 completed weeks

Each bar is one week. Gains rise above the zero line; losses fall below it. Taller bars mean a larger weekly move.

Weeks higher13 of 2613 weeks finished lower.
Best week+17.9%Week of 8 May.
Worst week-16.6%Week of 24 Jul.
Latest week+15.4%Week of 31 Jul.

Shape of recent returns

Strong gains8
Modest gains5
Flat weeks0
Modest losses1
Sharp losses12
Recent vol11.5%13-week weekly-return volatility.
Base vol8.6%52-week weekly-return volatility.
Up/down split23/29Count of positive and negative weeks in the 52-week window.
Average skew6.7% / -7.5%Average positive week versus average negative week.
07 · Sector and peer context

Is this stock leading—or simply moving with its group?

Sector and industry breadth distinguish company-specific strength from a broad group move.

08 · Evidence and weekly data

The underlying research record

Every top-level statement above should be traceable to a stored market, fundamental, event, or positioning observation.

Weekly tape14/100

Trend, activity pressure, participation, and risk combine to a 14/100 tape read.

 Indicator analysis24/100

Latest 12-week confirmation: trend 0/12, activity pressure 8/12, relative leadership 0/12.

Activity pressure 0.08; No reversal markers Next-Week ExpectancyNegative 44.78%

Next-week expectancy is negative with a 44.78% historical one-week setup read.

Adds short-term historical context without overriding trend, activity, or relative leadership. Factors38/100

O'Shaughnessy factor stack blends value, quality, momentum, and confidence.

Buyback Yield rank 85; Small Cap Core rank 59 Patient CapitalQuiet

Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.

No recent buy signal Options42/100

TLSA shows bullish options pressure with a 40/100 conviction score, put-call volume ratio of 0.27, expected move of 165.0%, and Sharemaestro trend signal inactive.

Bullish · Call-side pressure · Expected move 165.0% Sentiment55/100

Weighted news tone is neutral across 52 relevant articles.

Tiziana Life Sciences Announces Purchase of Shares by Chief Executive Officer Insiders50/100

No recent insider transaction evidence is stored.

 Earnings1d

Next report is scheduled for 07 Aug 2026; event risk rises as the date approaches.
WeekCloseReturnTrend LineFair ValuePressureLeadershipVolumeTrend
31 Jul 20261.03 USD15.4%1.30 USD1.11 USD-0.45-38.94840.6KOff
24 Jul 20260.89 USD-16.6%1.32 USD1.11 USD-0.15-47.951.8MOff
17 Jul 20261.07 USD-13.0%1.34 USD1.11 USD0.01-39.521.8MOff
10 Jul 20261.23 USD-6.1%1.36 USD1.11 USD0.04-33.98993.5KOff
3 Jul 20261.31 USD11.0%1.38 USD1.10 USD-0.03-28.93623.2KOff
26 Jun 20261.18 USD1.7%1.39 USD1.10 USD-0.04-35.86678.4KOff
19 Jun 20261.16 USD5.5%1.41 USD1.09 USD0.20-40.34950.2KOff
12 Jun 20261.10 USD-11.3%1.43 USD1.09 USD0.50-42.501.2MOff
5 Jun 20261.24 USD-12.1%1.45 USD1.09 USD0.73-34.371.2MOff
29 May 20261.41 USD-4.7%1.47 USD1.09 USD0.93-29.21932.1KOff
22 May 20261.48 USD8.0%1.49 USD1.08 USD0.70-23.942.3MOff
15 May 20261.37 USD-13.3%1.50 USD1.08 USD0.17-29.26846.1KOff
8 May 20261.58 USD17.9%1.52 USD1.08 USD-0.20-19.08798.5KOff
1 May 20261.34 USD3.9%1.54 USD1.07 USD-0.80-28.10662.9KOff
How to use this report

This is a completed-week research summary. It explains the available evidence and its conflicts; it does not predict a guaranteed outcome or replace your own risk assessment. Fundamental figures may refer to an earlier financial reporting period, which is shown above.