TYRA NASDAQ Week ended 31 Jul 2026

Weekly Investor Report

Tyra Biosciences Inc · Healthcare · Biotechnology

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Latest close 31.88 USD
4.1% latest week
Weekly setup

Mixed setup

The weekly trend is not active. Price is -2.3% below the Trend Line and sits at 71.4% of its 52-week range. The latest completed week returned 4.1%, after a 4.1% four-week move. The latest factor snapshot indicates quality is middle-of-the-pack; growth is moderate; valuation is neither clearly cheap nor expensive. Options positioning is volatility with 52/100 conviction, while the latest news-sentiment score is 54/100. Near-term considerations: volume confirmation is below normal; earnings are due in 11d.

Setup score 45 out of 100
Latest Close 31.88 USD 31 Jul 2026
1W Return 4.1% latest completed week
4W Return 4.1% short-term follow-through
12W Return -7.1% quarterly tape
Trend Breadth 76.9% 40 of 52 weeks active
Volume Ratio 0.8x vs 13-week average
What is working
  • Price is above Fair Value, showing premium demand versus the model.
What could go wrong
  • The trend backdrop is inactive, so price action has not confirmed a constructive regime.
  • Price is below the Trend Line, which keeps downside pressure in focus.
  • Activity pressure is negative, which weakens the current setup.
  • Next-week expectancy is negative at 44.86% based on similar historical setup states.
What to watch next
  • Trend Line remains the key weekly regime level.
  • Activity pressure is the gauge to monitor for confirmation or fade.
  • A volume ratio above 1.5x would show stronger participation in the next move.
Price follow-through 4.1% Latest completed week; four-week move 4.1%. Indicator stack 42/33 Trend and activity pressure are weighted against the latest 12-week confirmation window. Trend backdrop Active The trend backdrop defines the current weekly regime. Patient Capital Quiet Activity-pressure buy-signal status for institutional accumulation timing. Next-Week Expectancy Negative 44.86% Historical one-week expectancy contributes to the evidence score when direction is confirmed. Options pressure Volatility 52/100 conviction; expected move 31.3%. News sentiment 54/100 64 relevant articles in the latest sentiment read. Event risk 11d Next report is scheduled for 13 Aug 2026; event risk rises as the date approaches.
01 · Price action

Where price is—and whether the trend supports it

The weekly trend is not active. Price is -2.3% below the Trend Line and sits at 71.4% of its 52-week range. The latest completed week returned 4.1%, after a 4.1% four-week move.

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52-week price path

Price vs Trend Line and Fair Value
Price Trend Line Fair Value
02 · Volume and demand

Is real participation confirming the move?

Latest weekly volume is 0.8x the 13-week average. Participation is below its recent norm, so price strength is not receiving full volume confirmation.

26-week volume confirmation

Bar height shows volume; colour shows the weekly price direction
6 Feb 13 Feb 20 Feb 27 Feb 6 Mar 13 Mar 20 Mar 27 Mar 3 Apr 10 Apr 17 Apr 24 Apr 1 May 8 May 15 May 22 May 29 May 5 Jun 12 Jun 19 Jun 26 Jun 3 Jul 10 Jul 17 Jul 24 Jul 31 Jul
Up week Down week
Demand beneath price

Activity pressure and institutional-style signals

These indicators assess whether participation is improving beneath the headline price move. They are supporting evidence, not proof of institutional buying.

Activity pressure path

Latest 0.4412-week average 0.68

12-week confirmation

Trend active4/12Active trend-backdrop weeks in the latest 12-week window.
Positive pressure0/12Weeks with constructive activity pressure in the latest 12-week window.
Positive leadership12/12Weeks with positive relative leadership in the latest 12-week window.
Activity pressure0.44Current proprietary activity-pressure read.
Buy signals0Accumulation signal count in the latest 12 weeks.
Reversal markers11 reversal markers

No recent accumulation markers. 1 reversal markers.

03 · Momentum and leadership

Is performance persistent—and is the stock leading?

Performance is 4.1% over four weeks, -7.1% over 12 weeks, and 207.4% over one year. The current trend has remained active for 0 consecutive weeks.

Performance by holding period

1W4.1%
4W4.1%
12W-7.1%
26W3.4%
52W207.4%
Active trend streak0 weeks
Active weeks in one year40
Trend breadth76.9%

Activity pressure vs relative leadership

Activity pressureRelative leadership
Pressure-0.98Latest activity-pressure read.
Pressure change9.1%Four-week change in activity pressure.
Leadership14.14Latest relative-leadership reading.
RS change23.1%Four-week change in relative leadership.
04 · Fundamentals and valuation

What investors are paying for—and the quality behind it

The latest factor snapshot indicates quality is middle-of-the-pack; growth is moderate; valuation is neither clearly cheap nor expensive.

Open full factor analysis
Factor week 26 Jul 2026 Financial statements through 31 Mar 2026 Field coverage 67% Model confidence 64%

Relative factor standing

Higher display scores are better. Each score is converted from the underlying universe rank, where rank 1 is best.

Overall factor strength32/100Blend of value, momentum, and quality. Underlying universe rank 69; rank 1 is best.
Value42/100Relative valuation strength. Underlying universe rank 59; rank 1 is best.
Quality41/100Profitability and accounting quality. Underlying universe rank 60; rank 1 is best.
Momentum42/100Medium-term price momentum. Underlying universe rank 59; rank 1 is best.
Growth42/100Revenue and earnings growth. Underlying universe rank 59; rank 1 is best.
How to read this

Quality and valuation are separate questions

A strong company can still carry a demanding valuation. This report shows profitability, growth, balance-sheet strength, and the price paid for those characteristics separately.

Valuation

How much investors are paying for earnings, sales, and cash flow.

P/E
-
Price divided by trailing earnings.
Price / sales
-
Market value relative to trailing revenue.
EV / EBITDA
-
Enterprise value relative to operating cash earnings.
Free-cash-flow yield
-5.9%
Free cash flow as a share of enterprise value.

Business quality

Margins and the return generated on invested capital.

Gross margin
-
Gross profit retained from each unit of revenue.
Operating margin
-
Operating profit retained from revenue.
Free-cash-flow margin
-
Free cash flow generated from revenue.
Return on invested capital
-31.9%
Operating return generated on invested capital.

Growth and financial strength

Recent business growth and accounting strength.

Revenue growth
-
Latest one-year revenue growth.
EPS growth
-
Latest one-year earnings-per-share growth.
Free-cash-flow growth
-
Latest one-year free-cash-flow growth.
Piotroski F-score
1/9
Nine-point accounting-strength checklist.

Shareholder return and balance sheet

Cash returned to owners and financial leverage.

Dividend yield
-
Cash dividends relative to market value.
Buyback yield
-8.1%
Net share repurchases relative to market value.
Shareholder yield
-8.1%
Dividend yield plus net buyback yield.
Net debt / EBITDA
0.6x
Balance-sheet debt relative to operating cash earnings.
05 · Ownership, options, and sentiment

What other market participants are doing

Options, insider transactions, market sentiment, and activity-pressure signals can confirm or challenge the price story. None should be used alone.

Options positioningVolatility

TYRA shows volatility options pressure with a 52/100 conviction score, put-call volume ratio of 0.00, expected move of 31.3%, and Sharemaestro trend signal inactive.

Conviction52/100
Expected move31.3%
Put/call volume0.00
Pressure100
Speculation1
Volatility96
Trend agreement0
Open options detail
Insider activity18 / 0

18 acquisitions and 0 disposals in the latest 180-day insider tape.

Acquisitions / disposals over the latest 180 days. Insider activity is context, not a stand-alone signal.
News sentiment54/100

Weighted news tone is neutral across 64 relevant articles.

15 positive · 39 neutral · 10 negative
Patient CapitalQuiet

Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.

No recent buy signal
06 · Catalysts and risk

What can move the shares—and how volatile the path has been

Event timing, options-implied movement, drawdown, and weekly return distribution frame the risk around the current setup.

Next earnings11dNext report is scheduled for 13 Aug 2026; event risk rises as the date approaches.
Options expected move31.3%Nearest-chain priced movement where available.
52-week drawdown-21.6%Distance below the 52-week high.
13-week volatility8.4%Standard deviation of weekly returns.

Weekly gains and losses

Latest 26 completed weeks

Each bar is one week. Gains rise above the zero line; losses fall below it. Taller bars mean a larger weekly move.

Weeks higher17 of 269 weeks finished lower.
Best week+12.8%Week of 20 Feb.
Worst week-20.3%Week of 5 Jun.
Latest week+4.1%Week of 31 Jul.

Shape of recent returns

Strong gains10
Modest gains7
Flat weeks0
Modest losses3
Sharp losses6
Recent vol8.4%13-week weekly-return volatility.
Base vol8.1%52-week weekly-return volatility.
Up/down split35/17Count of positive and negative weeks in the 52-week window.
Average skew6.5% / -5.6%Average positive week versus average negative week.
07 · Sector and peer context

Is this stock leading—or simply moving with its group?

Sector and industry breadth distinguish company-specific strength from a broad group move.

08 · Evidence and weekly data

The underlying research record

Every top-level statement above should be traceable to a stored market, fundamental, event, or positioning observation.

Weekly tape44/100

Trend, activity pressure, participation, and risk combine to a 44/100 tape read.

 Indicator analysis42/100

Latest 12-week confirmation: trend 4/12, activity pressure 0/12, relative leadership 12/12.

Activity pressure 0.44; 1 reversal markers Next-Week ExpectancyNegative 44.86%

Next-week expectancy is negative with a 44.86% historical one-week setup read.

Adds short-term historical context without overriding trend, activity, or relative leadership. Factors38/100

O'Shaughnessy factor stack blends value, quality, momentum, and confidence.

Buyback Yield rank 85; Small Cap Core rank 59 Patient CapitalQuiet

Activity-pressure buy-signal evidence highlights potential institutional accumulation windows.

No recent buy signal Options35/100

TYRA shows volatility options pressure with a 52/100 conviction score, put-call volume ratio of 0.00, expected move of 31.3%, and Sharemaestro trend signal inactive.

Volatility · Volatility expansion watch · Expected move 31.3% Sentiment54/100

Weighted news tone is neutral across 64 relevant articles.

BlackRock (TYRA holder) reports 2.98M TYRA Biosciences shares, a 5% passive stake Insiders18 / 0

18 acquisitions and 0 disposals in the latest 180-day insider tape.

 Earnings11d

Next report is scheduled for 13 Aug 2026; event risk rises as the date approaches.
WeekCloseReturnTrend LineFair ValuePressureLeadershipVolumeTrend
31 Jul 202631.88 USD4.1%32.63 USD18.69 USD-0.9814.142.9MOff
24 Jul 202630.63 USD-4.7%32.46 USD18.58 USD-1.0911.732.3MOff
17 Jul 202632.13 USD-1.9%32.31 USD18.47 USD-0.9816.742.7MOff
10 Jul 202632.75 USD7.0%32.09 USD18.37 USD-1.0515.603.5MOff
3 Jul 202630.62 USD-4.0%31.75 USD18.25 USD-1.0811.492.9MOff
26 Jun 202631.88 USD12.6%31.45 USD18.15 USD-1.0718.557.4MOff
19 Jun 202628.32 USD4.9%31.14 USD18.06 USD-1.222.044.9MOff
12 Jun 202626.99 USD1.3%30.89 USD17.99 USD-1.210.925.6MOff
5 Jun 202626.64 USD-20.3%30.52 USD17.92 USD-1.092.855.4MOn
29 May 202633.41 USD2.9%30.11 USD17.85 USD-1.0224.342.5MOn
22 May 202632.47 USD-12.3%29.52 USD17.73 USD-0.8826.183.9MOn
15 May 202637.04 USD7.9%28.92 USD17.61 USD-0.5747.823.1MOn
8 May 202634.32 USD0.8%28.16 USD17.46 USD-0.3639.023.3MOn
1 May 202634.04 USD-9.4%27.47 USD17.32 USD-0.1247.725.2MOn
How to use this report

This is a completed-week research summary. It explains the available evidence and its conflicts; it does not predict a guaranteed outcome or replace your own risk assessment. Fundamental figures may refer to an earlier financial reporting period, which is shown above.