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Spyre Therapeutics launches public stock offering

Spyre Therapeutics Inc. has announced the commencement of an underwritten public offering of its common stock, with plans to grant underwriters an option to purchase additional shares. The biotechnology company intends to use the net proceeds to advance its gastroenterology, rheumatology, and dermatology programs, โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

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External headlines link to their original source. Market context comes from stored weekly company data, not from an opinion about the article.

Wells Fargo Maintains Spyre Therapeutics(SYRE.US) With Buy Rating, Maintains Target Price $115

Wells Fargo has reiterated its Buy rating for Spyre Therapeutics (SYRE.US), maintaining its price target at $115. This suggests continued confidence from Wells Fargo in the company's financial prospects and stock performance.

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre Therapeuticsโ€™ chief legal officer sells $2.63m in shares

Spyre Therapeutics' chief legal officer, Heidy King-Jones, sold shares worth over $2.63 million on October 1, 2026, after exercising stock options. These transactions were executed under a Rule 10b5-1 trading plan. Despite the stock's significant surge over the past year, InvestingPro analysis suggests it โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

CEO Cameron Turtle Sells 15,000 Shares of Spyre Therapeutics Inc (SYRE)

Cameron Turtle, CEO of Spyre Therapeutics Inc (SYRE), sold 15,000 shares of the company on October 1, 2026, at $92.01 per share. This transaction is part of a larger trend of insider selling at SYRE, with 30 insider sells and 0 buys over the โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre Therapeutics CEO Cameron Turtle sells $1.38m in SYRE stock

Spyre Therapeutics CEO Cameron Turtle sold 14,000 shares of SYRE stock for approximately $1.38 million on October 1, 2026, under a Rule 10b5-1 trading plan. This sale follows a significant 487% surge in the stock over the past year, though InvestingPro analysis suggests it's โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

After exercising $14.50 options, Spyre Therapeutics (SYRE) legal chief sells 28,933 shares.

Heidy King-Jones, Chief Legal Officer and Corporate Secretary of Spyre Therapeutics (SYRE), exercised options for 28,933 common shares at $14.50 per share on October 1, 2026. She subsequently sold these shares in five separate transactions under a Rule 10b5-1 trading plan, with weighted-average sale โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre Therapeutics Officer Heidy King-Jones Files Form 144 to Sell 29,335 Shares Under 10b5-1 Plan

Heidy King-Jones, an officer at Spyre Therapeutics (NASDAQ:SYRE), has filed a Form 144 to sell 29,335 shares of common stock, valued at over $2.6 million, under a pre-established Rule 10b5-1 trading plan. These shares will be acquired through stock option exercises. King-Jones has also โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

J.P. Morgan Initiates Spyre Therapeutics(SYRE.US) With Buy Rating, Announces Target Price $110

J.P. Morgan has initiated coverage on Spyre Therapeutics (SYRE.US) with a "Buy" rating. The investment bank has set a target price of $110 for the company's stock. This new rating and price target indicate a positive outlook from J.P. Morgan regarding Spyre Therapeutics' future โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

After a $2.44M September sale, an officer proposes selling more Spyre Therapeutics (SYRE) shares.

Heidy King-Jones, an officer at Spyre Therapeutics (SYRE), plans to sell 29,335 common shares worth approximately $2.61 million on October 1, 2026. This proposed sale follows two previous 10b5-1 sales by King-Jones in September 2026, totaling over $2.4 million. The shares were and will โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre stock draws new Overweight at J.P. Morgan (SYRE:NASDAQ)

J.P. Morgan initiated coverage on Spyre Therapeutics (SYRE) with an Overweight rating and a $110 price target for year-end 2027. Analyst Hardik Parikh highlighted the company's strong potential in treating inflammatory bowel disease (IBD) as the primary driver for the positive outlook. This news โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

SYRE Stock Steadies As SPY003 Data Resets Biotech Expectations

Spyre Therapeutics (SYRE) stock is up 5.22% after positive Phase 2 SKYLINE data for its SPY003 drug, which met its primary endpoint for ulcerative colitis. Despite the strong clinical results, shares traded modestly lower initially, suggesting high market expectations and a "wait and see" โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

SYRE Stock Steadies As SPY003 Trial Data De-Risks IBD Pipeline

Spyre Therapeutics (SYRE) stock is trending up after positive Phase 2 SKYLINE trial data for SPY003 in ulcerative colitis, hitting its primary endpoint and de-risking its IBD pipeline. This win, combined with validated SPY001 and SPY002, establishes a multi-mechanism IBD platform. Despite strong data, โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre Therapeutics gains as investors continue to digest positive Phase 2 bowel disease data

Spyre Therapeutics (SYRE) saw a 5.1% increase in its stock price, likely due to sustained investor confidence following positive Phase 2 clinical trial results for its ulcerative colitis treatment, SPY003. The company announced strong 12-week topline results in early September, meeting its primary endpoint โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

Spyre Therapeutics (SYRE) Stock Price, News & Analysis

Spyre Therapeutics (SYRE) is a clinical-stage biotechnology company developing long-acting antibodies for inflammatory bowel disease (IBD) and rheumatic diseases. The company's pipeline includes investigational antibodies SPY001, SPY002, SPY072, and SPY003, designed for infrequent subcutaneous dosing, and it is exploring rational combinations of these therapies. โ€ฆ

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

JonesTrading Maintains Spyre Therapeutics(SYRE.US) With Buy Rating, Maintains Target Price $121

JonesTrading has reaffirmed its Buy rating for Spyre Therapeutics (SYRE.US) and maintained its target price at $121. This indicates continued confidence from the firm in the company's prospects and valuation.

SYRE main company
Sharemaestro market context Trend signal active 52 weeks +386.9% SYRE stored weekly price path from 10 Oct 2025 to 2 Oct 2026

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