Weekly structural research · NASDAQ · Healthcare

GPCR Stage Analysis

Structure Therapeutics Inc. American Depositary Shares

Week ending 9 Oct 2026Close USD 25.54Tenure NewBenchmark QQQ

Screen this regime Supporting research Report data ↗

Executive diagnosis

What the Activity Line geometry says now

Structure, not prediction

Downward Expansion · Early contraction

The weekly architecture is expanding downward.

Trend and Activity show sustained negative alignment with weak price acceptance. Repair requires persistent improvement across the structure, not merely one strong observation.

The Trend gate is down within the current regime.
Fast Activity versus Slow Activity: weakening.
Activity structure: wide and expanding.

Direction -87−100 bearish to +100 bullish

Energy 94/100directional strength

Maturity 26/100lifecycle context

Confidence 79/100evidence agreement

Trend gate Downstructural direction

Activity structure Wideexpanding separation

Price acceptance -100.0%position within the Activity structure

Fair Value context -35.5%USD 39.60 · weakening

Trend Architecture map · Historical context

Weekly close, Activity, Trend and Fair Value

Follow price and Trend first, then add Activity Lines to inspect the structure. Subtle bands show the regime recognized at each completed observation; the dashed line marks current Fair Value, not a historical forecast.

CloseTrendCurrent Fair Value

Background stage key

BalanceDirection is contained.
Rotation UpStructure is turning higher.
Upward ExpansionUptrend is established.
DecelerationUptrend is losing energy.
Rotation DownStructure is turning lower.
Downward ExpansionDowntrend is established.

View chart values · 156 observations

Week	Close	Trend	Relative Strength	Volume	Regime	Direction	Energy
2026-10-09	25.54	44.62	-55.71	5872195	Downward Expansion	-87	94
2026-10-02	27.67	45.56	-52.11	9516559	Downward Expansion	-90	91
2026-09-25	35.93	46.57	-37.52	6733420	Downward Expansion	-75	78
2026-09-18	35.00	47.47	-37.03	7345703	Balance	-70	65
2026-09-11	38.66	48.52	-29.65	7017886	Balance	-50	35
2026-09-04	47.34	49.57	-13.95	4179517	Balance	1	5
2026-08-28	47.37	50.49	-12.99	3143994	Balance	-20	15
2026-08-21	49.09	51.85	-8.71	3724638	Balance	-4	12
2026-08-14	54.51	53.23	-0.30	3339971	Balance	10	17
2026-08-07	53.14	54.37	-0.71	2581821	Balance	6	11
2026-07-31	48.04	54.88	-4.56	2234090	Balance	-7	14
2026-07-24	49.12	55.55	-0.88	2643723	Balance	-4	22
2026-07-17	48.48	56.19	-2.70	3310769	Balance	-3	26
2026-07-10	53.36	56.74	3.62	3173593	Downward Expansion	5	28
2026-07-03	53.45	57.20	6.80	4223521	Downward Expansion	-14	27
2026-06-26	49.71	56.57	1.25	5063035	Downward Expansion	-41	28
2026-06-19	44.51	56.11	-12.66	3607200	Downward Expansion	-49	44
2026-06-12	42.93	55.77	-13.05	5365933	Downward Expansion	-62	54
2026-06-05	37.58	55.56	-21.73	3162445	Downward Expansion	-69	79
2026-05-29	39.34	55.40	-21.46	1765778	Downward Expansion	-66	81
2026-05-22	39.19	55.20	-19.24	3899110	Rotation Down	-70	84
2026-05-15	38.69	54.78	-19.16	3003087	Rotation Down	-47	74
2026-05-08	39.10	54.40	-18.42	4230857	Rotation Down	-50	68
2026-05-01	42.21	54.10	-7.02	5619121	Rotation Down	-46	40
2026-04-24	45.49	53.60	1.95	4161927	Rotation Down	-33	32
2026-04-17	50.75	52.92	16.85	4077401	Rotation Down	-25	33
2026-04-10	54.51	52.01	34.39	4625186	Rotation Down	-23	40
2026-04-03	53.48	50.89	39.92	5716389	Deceleration	-24	47
2026-03-27	45.92	49.85	27.00	4839754	Deceleration	-18	43
2026-03-20	48.59	48.96	31.60	7373291	Deceleration	-14	32
2026-03-13	53.75	47.99	44.45	3557994	Deceleration	6	26
2026-03-06	57.73	46.87	55.80	3966261	Deceleration	27	27
2026-02-27	62.98	45.49	70.52	3693987	Deceleration	38	27
2026-02-20	66.55	43.98	83.02	3710011	Upward Expansion	47	38
2026-02-13	70.07	42.36	99.00	3772541	Upward Expansion	63	57
2026-02-06	74.92	40.66	115.08	6556030	Upward Expansion	67	66
2026-01-30	88.45	38.80	154.96	3148849	Upward Expansion	77	74
2026-01-23	90.37	36.53	167.95	5996446	Upward Expansion	86	81
2026-01-16	88.64	34.22	172.30	8667898	Upward Expansion	92	89
2026-01-09	68.61	31.99	116.14	5344627	Upward Expansion	70	88
2026-01-02	68.12	30.43	124.39	2742989	Upward Expansion	76	90
2025-12-26	68.34	28.86	126.26	4713041	Upward Expansion	86	89
2025-12-19	64.94	27.31	122.41	7228211	Upward Expansion	91	81
2025-12-12	67.06	25.96	135.86	31056305	Upward Expansion	95	72
2025-12-05	34.56	24.57	21.78	4965476	Upward Expansion	66	66
2025-11-28	35.81	24.27	27.00	4069907	Upward Expansion	72	83
2025-11-21	34.32	23.97	27.33	9728143	Upward Expansion	68	84
2025-11-14	36.82	23.62	31.93	6105937	Upward Expansion	87	89
2025-11-07	32.84	23.12	17.07	3878347	Upward Expansion	78	69
2025-10-31	33.32	22.56	14.16	4227745	Upward Expansion	87	84
2025-10-24	26.39	21.95	-9.04	3561106	Upward Expansion	65	78
2025-10-17	27.38	21.73	-4.87	5108499	Upward Expansion	67	83
2025-10-10	30.07	21.51	5.54	5408835	Upward Expansion	91	92
2025-10-03	27.28	21.21	-7.42	5575041	Rotation Up	76	79
2025-09-26	25.00	21.06	-15.57	5353256	Rotation Up	42	53
2025-09-19	23.58	21.02	-22.06	4891204	Downward Expansion	32	30
2025-09-12	20.91	21.02	-30.66	4193601	Downward Expansion	-20	20
2025-09-05	22.08	21.14	-26.82	11267095	Downward Expansion	-14	17
2025-08-29	19.30	21.32	-36.44	2200075	Downward Expansion	-42	27
2025-08-22	19.61	21.67	-36.66	3703063	Downward Expansion	-56	37
2025-08-15	20.12	21.96	-36.72	4751685	Downward Expansion	-62	59
2025-08-08	16.31	22.19	-49.23	6562547	Downward Expansion	-78	78
2025-08-01	17.59	22.49	-44.11	3424549	Downward Expansion	-72	73
2025-07-25	17.94	22.83	-45.16	3324951	Downward Expansion	-71	67
2025-07-18	19.25	23.20	-41.63	4769196	Downward Expansion	-64	58
2025-07-11	19.01	23.49	-42.47	3631856	Balance	-65	50
2025-07-04	20.36	23.89	-39.66	1643541	Balance	-58	41
2025-06-27	21.08	24.33	-37.41	4409218	Balance	-44	31
2025-06-20	21.73	24.73	-33.71	2621477	Balance	-40	28
2025-06-13	21.68	25.12	-34.97	4807093	Balance	-38	25
2025-06-06	21.13	25.53	-38.10	4316736	Balance	-38	20
2025-05-30	21.76	26.10	-36.37	4448250	Balance	-19	15
2025-05-23	24.55	26.74	-27.54	2304434	Downward Expansion	-5	21
2025-05-16	25.17	27.18	-28.15	4044591	Downward Expansion	-16	27
2025-05-09	25.57	27.66	-22.70	3565253	Downward Expansion	-15	25
2025-05-02	27.09	28.08	-18.92	4845130	Downward Expansion	-21	18
2025-04-25	23.74	28.61	-27.23	5717280	Downward Expansion	-60	46
2025-04-18	21.76	29.21	-29.82	8674349	Downward Expansion	-65	59
2025-04-11	15.90	29.88	-50.42	4908413	Downward Expansion	-79	87
2025-04-04	15.12	30.71	-50.06	6319355	Downward Expansion	-89	90
2025-03-28	19.77	31.44	-42.06	3887643	Downward Expansion	-76	81
2025-03-21	20.97	32.05	-40.84	2206940	Downward Expansion	-74	80
2025-03-14	21.05	32.68	-41.28	4504875	Downward Expansion	-77	81
2025-03-07	22.62	33.22	-39.05	4322895	Downward Expansion	-72	77
2025-02-28	23.75	33.59	-38.67	5200276	Downward Expansion	-69	67
2025-02-21	23.76	33.99	-41.40	2718655	Downward Expansion	-72	55
2025-02-14	24.39	34.49	-41.91	3712583	Downward Expansion	-72	48
2025-02-07	27.40	34.92	-33.84	3681442	Downward Expansion	-60	41
2025-01-31	29.97	35.47	-28.60	4542631	Downward Expansion	-59	46
2025-01-24	28.22	35.73	-34.41	2765745	Downward Expansion	-63	59
2025-01-17	27.06	36.10	-36.86	5206880	Downward Expansion	-65	71
2025-01-10	25.26	36.72	-40.01	3111135	Downward Expansion	-78	81
2025-01-03	27.76	37.48	-36.45	2529483	Downward Expansion	-72	74
2024-12-27	29.04	38.33	-34.82	2403890	Downward Expansion	-70	72
2024-12-20	27.90	38.50	-37.44	7796471	Downward Expansion	-79	74
2024-12-13	31.25	38.80	-32.01	4363168	Downward Expansion	-70	68
2024-12-06	33.35	38.97	-28.28	4428578	Downward Expansion	-60	64
2024-11-29	33.15	39.05	-27.87	2788645	Downward Expansion	-64	63
2024-11-22	33.41	39.25	-28.10	5694109	Balance	-64	54
2024-11-15	34.17	39.44	-26.14	3878109	Balance	-64	43
2024-11-08	38.02	39.51	-21.78	3283750	Balance	-10	9
2024-11-01	41.14	39.56	-12.01	3867414	Balance	4	7
2024-10-25	37.59	39.57	-22.54	2520590	Balance	-18	10
2024-10-18	39.50	39.74	-20.39	4210398	Balance	6	7
2024-10-11	38.32	39.85	-24.22	3178284	Balance	3	12
2024-10-04	42.99	39.75	-15.54	2893044	Balance	54	36
2024-09-27	41.75	39.55	-18.83	4525083	Balance	13	14
2024-09-20	41.92	39.53	-18.49	4011207	Balance	3	7
2024-09-13	40.84	39.48	-19.53	4723072	Downward Expansion	-21	12
2024-09-06	36.95	39.65	-22.91	1431675	Downward Expansion	-37	17
2024-08-30	38.13	40.05	-24.96	2303209	Downward Expansion	-44	22
2024-08-23	39.79	40.24	-22.28	2953444	Downward Expansion	-47	28
2024-08-16	37.12	40.33	-26.73	3054703	Downward Expansion	-50	39
2024-08-09	33.77	40.45	-29.70	3259245	Downward Expansion	-59	45
2024-08-02	35.88	—	—	3172394	Not yet classified	—	—
2024-07-26	38.65	—	—	3698852	Not yet classified	—	—
2024-07-19	37.44	—	—	8365328	Not yet classified	—	—
2024-07-12	43.88	—	—	4628660	Not yet classified	—	—
2024-07-05	37.77	—	—	2635335	Not yet classified	—	—
2024-06-28	39.27	—	—	6728393	Not yet classified	—	—
2024-06-21	45.57	—	—	3309768	Not yet classified	—	—
2024-06-14	48.17	—	—	7075443	Not yet classified	—	—
2024-06-07	53.07	—	—	24022597	Not yet classified	—	—
2024-05-31	34.20	—	—	2127033	Not yet classified	—	—
2024-05-24	37.06	—	—	2956542	Not yet classified	—	—
2024-05-17	36.15	—	—	2550787	Not yet classified	—	—
2024-05-10	35.82	—	—	2086387	Not yet classified	—	—
2024-05-03	39.29	—	—	2544227	Not yet classified	—	—
2024-04-26	38.94	—	—	2574384	Not yet classified	—	—
2024-04-19	36.36	—	—	2004761	Not yet classified	—	—
2024-04-12	39.32	—	—	2704511	Not yet classified	—	—
2024-04-05	41.46	—	—	1629894	Not yet classified	—	—
2024-03-29	42.86	—	—	2869867	Not yet classified	—	—
2024-03-22	42.88	—	—	4988243	Not yet classified	—	—
2024-03-15	35.25	—	—	3261425	Not yet classified	—	—
2024-03-08	36.86	—	—	5708260	Not yet classified	—	—
2024-03-01	41.24	—	—	2983238	Not yet classified	—	—
2024-02-23	40.51	—	—	1184042	Not yet classified	—	—
2024-02-16	45.80	—	—	2329783	Not yet classified	—	—
2024-02-09	49.00	—	—	1814124	Not yet classified	—	—
2024-02-02	43.78	—	—	1935613	Not yet classified	—	—
2024-01-26	42.50	—	—	2109313	Not yet classified	—	—
2024-01-19	40.77	—	—	1810626	Not yet classified	—	—
2024-01-12	45.80	—	—	3415488	Not yet classified	—	—
2024-01-05	42.36	—	—	3061774	Not yet classified	—	—
2023-12-29	40.76	—	—	3126211	Not yet classified	—	—
2023-12-22	35.59	—	—	21966193	Not yet classified	—	—
2023-12-15	59.16	—	—	3788977	Not yet classified	—	—
2023-12-08	61.87	—	—	2832582	Not yet classified	—	—
2023-12-01	59.57	—	—	3477920	Not yet classified	—	—
2023-11-24	51.52	—	—	1440873	Not yet classified	—	—
2023-11-17	53.77	—	—	6225279	Not yet classified	—	—
2023-11-10	54.87	—	—	4193597	Not yet classified	—	—
2023-11-03	69.88	—	—	2756673	Not yet classified	—	—
2023-10-27	68.17	—	—	3658869	Not yet classified	—	—
2023-10-20	67.52	—	—	2978795	Not yet classified	—	—

Price vs TrendBelow-42.8%

Trend directionFalling-18.7%

Price vs current Fair ValueBelow anchor-35.5%

Fair Value directionMoving away-72.0%

Relative Strength vs benchmarkLagging-55.7%

Relative strength directionWeakening-59.3%

Price momentumNegative-53.1%

Volume balanceSupply-led0.33×

Beyond the current label

Is the structure strengthening or losing force?

Direction and energy measure different things

Direction shows the upward or downward lean. Energy shows the force behind the structural move: high energy can accompany a strong decline as well as an advance.

Direction

-87 / ±100

-36.7 points since 2026-09-11

Energy

94 /100

+59.5 points since 2026-09-11

Recent change compares the latest reading with four observations earlier. Missing readings remain unavailable. Use the chart values above to inspect individual observations.

GPCR Directional State ↗ GPCR Momentum Intelligence ↗

Comparative structural evidence

Why this architecture regime won

Every regime is evaluated

Balance17

Rotation Up8

Upward Expansion22

Deceleration37

Rotation Down88

Downward Expansion100

The winning regime is the state most consistent with the complete SM evidence set. Direction, energy, maturity and confidence describe different aspects of the current structure, while contradictory evidence remains visible rather than being averaged into false certainty.

Time spent in each state

The context behind today’s regime

2023-10-20 to 2026-10-09 · 114 classified observations out of 156 shown.

Balance 24%Rotation Up 2%Upward Expansion 18%Deceleration 5%Rotation Down 6%Downward Expansion 46%

Recent Trend Architecture ledger

Regime	Recognized	Last observation	Tenure	Move inside regime
Downward Expansion	2026-09-25	2026-10-09	New	-28.9%
Balance	2026-07-17	2026-09-18	Developing	-27.8%
Downward Expansion	2026-05-29	2026-07-10	Developing	+35.6%
Rotation Down	2026-04-10	2026-05-22	Developing	-28.1%
Deceleration	2026-02-27	2026-04-03	Developing	-15.1%
Upward Expansion	2025-10-10	2026-02-20	Established	+121.3%
Rotation Up	2025-09-26	2025-10-03	New	+9.1%
Downward Expansion	2025-07-18	2025-09-19	Developing	+22.5%
Balance	2025-05-30	2025-07-11	Developing	-12.6%
Downward Expansion	2024-11-29	2025-05-23	Established	-25.9%
Balance	2024-09-20	2024-11-22	Developing	-20.3%
Downward Expansion	2024-08-09	2024-09-13	Developing	+20.9%

Classic Stage Analysis comparison

Stage 1 · Basing49

Stage 2 · Advancing0

Stage 3 · Distribution21

Stage 4 · Declining100

Legacy result: Stage 4 · Stage 4B · Declining. It remains visible while the experimental architecture is validated rather than being silently discarded.

Leadership versus QQQ

Is relative performance confirming the geometry?

Confirmation, not classification

Relative Strength

The security is compared with its market benchmark on the SM scale. Above zero indicates relative leadership; direction shows whether that leadership is improving or weakening.

Confirmation evidence

Lagging benchmark

Architecture confirmation: 99/100
Current Relative Strength: -55.71
Relative Strength direction: Weakening
Price momentum: -53.1%
Excess performance vs benchmark: -76.1%
Healthcare regime cohort: 62th percentile286 in cohort

Test GPCR trend persistence

Participation and structure

Is demand confirming the architecture?

Volume cannot overrule geometry

Relative volume1.33×

Latest completed volume relative to typical participation.

Up/down volume0.33×

Participation balance between advancing and declining observations.

Accumulation / distribution1 / 4

Recent participation evidence classified by demand and supply.

Activity alignment+0.0%

Current positive alignment across Activity and Trend.

Fast/slow rotationWeakening

Current relationship between Fast Activity and Slow Activity.

Structure stability+50.0%

Whether recent Activity evidence is stable or remains in balance.

Weekly volume with architecture context

Bars show completed weekly volume; the dashed line provides typical-volume context. Both measures use the same scale.

Explore GPCR Volume & Price ↗

Decision architecture

References that would change the structural read

Evidence levels, not orders

Fast Activity USD 30.32falling

Slow Activity USD 43.06falling

Trend Reference USD 44.62-42.8% close margin

Current Fair Value USD 39.60-35.5% close margin

Structural low USD 25.09shock / repair context

What changes the read?

Fan contraction and a persistent upward fast/slow rotation are required before the declining structure is considered repaired.

Range context +22.7%

Annualized volatility +64.0%

From structural high -73.1%

From structural low +1.8%

Point-in-time evidence

What followed this architecture in this market?

Descriptive history, never a forecast

Historical comparisons use only the structural read that would have been available at each completed observation. Independent observations are used where possible, with benchmark comparison beginning after each recognized state.

Outcome horizon	Samples	Median move	Positive periods	Directional follow-through	Median excess vs QQQ	Regime survived	Read
Near term	14	+3.8%-15.8% to +43.8%	+57.1%	+42.9%	+1.8%	+71.4%	Usable descriptive sample
Intermediate	5	+12.6%-28.4% to +42.2%	+60.0%	+40.0%	-1.7%	+20.0%	Usable descriptive sample
Extended	3	-18.9%-40.5% to +359.4%	+33.3%	+66.7%	-35.3%	+66.7%	Too little matched history
Full cycle	2	+87.1%-51.7% to +225.8%	+50.0%	+50.0%	+59.8%	+50.0%	Too little matched history

Evidence framework

What the analysis measures and where its limits lie

Trend Architecture

Trend Architecture brings Price, Fast Activity, Slow Activity and Trend into one structural read. It identifies balance, rotation, expansion, deceleration and contraction while requiring persistent evidence for confirmed regime changes.

Evidence roles

Trend, Activity, relative strength, volume and Fair Value each have a defined role in the SM evidence framework. No single reading is treated as sufficient on its own, and conflicting evidence remains visible.

Fair Value and RS

Current Fair Value provides a long-term price anchor and shows whether price is trading above, below or repairing toward that reference. Relative Strength compares the security with its benchmark and shows whether leadership is improving or weakening.

Known limitations

Weekly structure recognizes conditions after they develop. Event gaps can bypass smooth transitions, sideways markets can rotate repeatedly, and historical samples for a particular regime can be thin.

Independent market research for education. Not investment advice, a recommendation, a forecast, a target, or an execution instruction. Historical regime behaviour does not establish what happens next.

GPCR Stage Analysis

What the Activity Line geometry says now

The weekly architecture is expanding downward.

Weekly close, Activity, Trend and Fair Value

Is the structure strengthening or losing force?

Direction

Energy

Why this architecture regime won

The context behind today’s regime

Is relative performance confirming the geometry?

Relative Strength

Lagging benchmark

Is demand confirming the architecture?

Weekly volume with architecture context

References that would change the structural read

What followed this architecture in this market?

What the analysis measures and where its limits lie

Trend Architecture

Evidence roles

Fair Value and RS

Known limitations

Send a message

Evidence context

What the Activity Line geometry says now

The weekly architecture is expanding downward.

Weekly close, Activity, Trend and Fair Value

Is the structure strengthening or losing force?

Direction

Energy

Why this architecture regime won

The context behind today’s regime

Is relative performance confirming the geometry?

Relative Strength ?

Lagging benchmark

Is demand confirming the architecture?

Weekly volume with architecture context

References that would change the structural read

What followed this architecture in this market?

Test the structure from another angle

Trend Persistence ↗

Directional State ↗

Momentum Intelligence ↗

Volume & Price ↗

Similar Charts ↗

RMI Reversal Map ↗

What the analysis measures and where its limits lie

Trend Architecture

Evidence roles

Fair Value and RS

Known limitations

Relative Strength

Trend Persistence

Directional State

Momentum Intelligence

Volume & Price

Similar Charts

RMI Reversal Map