Balanced news tone
News Sentiment
SYRE sentiment intelligence
Spyre Therapeutics Inc. news scored across direct company coverage, industry context, sector read-through, source quality, and freshness.
Price is moving more forcefully than the current news tone suggests.
84/100 classification confidence.
directly relevant articles
high-authority source matches
+12.8% over one week, +21.0% over four weeks, trend active, and materially above fair value.
Why Spyre Therapeutics (SYRE) Stock Is Up Today
Market Reaction
Price moving ahead of tone
Price is moving more forcefully than the current news tone suggests.
Sentiment Mix
Positive, neutral, negative
Relevance
Why the article matched
Sources
Coverage mix
Event Lens
What the news is about
Sentiment Trail
Score over time
News Tape
Relevant headlines
Why Spyre Therapeutics (SYRE) Stock Is Up Today
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 14 Jul 2026 18:36
- Source
- Quiver Quantitative
Unpacking Q1 Earnings: Incyte (NASDAQ:INCY) In The Context Of Other Biotechnology Stocks
- Tone
- Neutral 50/100
- Event
- Earnings
- Published
- 13 Jul 2026 12:30
- Source
- Market source
Mizuho Raises Price Target on Spyre Therapeutics to $120 From $84, Keeps Outperform Rating
- Tone
- Positive 66/100
- Event
- Analyst action
- Published
- 13 Jul 2026 10:58
- Source
- MT Newswires
SYRE News | SPYRE THERAPEUTICS INC (NASDAQ:SYRE)
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 11 Jul 2026 00:00
- Source
- ChartMill
Spyre Therapeutics (SYRE) Faces Broad Russell Index Removal Is Benchmark Appeal Quietly Eroding?
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 10 Jul 2026 02:27
- Source
- simplywall.st
Spyre Therapeutics Insider Sold Shares Worth $1,315,346, According to a Recent SEC Filing
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 06 Jul 2026 07:53
- Source
- MT Newswires
Spyre Therapeutics Announces Grants of Inducement Awards
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 02 Jul 2026 20:05
- Source
- GlobeNewswire
Spyre Therapeutics (SYRE) CFO exercises options, sells 7,500 shares under 10b5-1 plan
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 02 Jul 2026 07:00
- Source
- Stock Titan
Spyre gives six new hires equity awards worth 58,843 options
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 02 Jul 2026 07:00
- Source
- Stock Titan
SYRE (NASDAQ) Form 144: Insider sales and 45,000-share notice
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 01 Jul 2026 07:00
- Source
- Stock Titan
Spyre Therapeutics: Deep And Diverse Immunology Pipeline Awaiting Data (NASDAQ:SYRE)
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 30 Jun 2026 07:00
- Source
- Seeking Alpha
Spyre Therapeutics Insider Sold Shares Worth $1,307,000, According to a Recent SEC Filing
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 29 Jun 2026 07:16
- Source
- MT Newswires
Spyre Therapeutics Stock Outlook Hinges on 2026 Study Catalysts
- Tone
- Neutral 50/100
- Event
- Guidance
- Published
- 29 Jun 2026 07:00
- Source
- Market source
Spyre Therapeutics (NASDAQ: SYRE) launches $500M at‑the‑market program
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 26 Jun 2026 07:00
- Source
- Stock Titan
Spyre Therapeutics CFO Burrows sells $1.3m in SYRE stock
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 26 Jun 2026 07:00
- Source
- Investing.com
SYRE (NASDAQ): Affiliate files Form 144 to sell 15,000 shares on 06/25/2026
- Tone
- Negative 34/100
- Event
- Market update
- Published
- 25 Jun 2026 07:00
- Source
- Stock Titan
Spyre Therapeutics Shares Fall After Director Sells $2 Million in Stock
- Tone
- Negative 30/100
- Event
- Market update
- Published
- 24 Jun 2026 18:40
- Source
- MT Newswires
Spyre Therapeutics Insider Sold Shares Worth $2,000,000, According to a Recent SEC Filing
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 24 Jun 2026 07:39
- Source
- MT Newswires
Spyre Therapeutics Shares Slide Following Large Insider Stock Sales (SYRE)
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 24 Jun 2026 07:00
- Source
- Market source
Spyre stock falls after $2M insider sale (SYRE:NASDAQ)
- Tone
- Negative 22/100
- Event
- Market update
- Published
- 24 Jun 2026 07:00
- Source
- Seeking Alpha
Deutsche Bank Adjusts Spyre Therapeutics Price Target to $135 From $115, Maintains Buy Rating
- Tone
- Positive 58/100
- Event
- Analyst action
- Published
- 23 Jun 2026 11:27
- Source
- MT Newswires
Spyre (SYRE) fund converts Series B preferred, then exits common stake
- Tone
- Neutral 50/100
- Event
- Deals and strategy
- Published
- 23 Jun 2026 07:00
- Source
- Stock Titan
Director at Spyre Therapeutics (SYRE) sells 20,000 shares under 10b5-1 plan
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 23 Jun 2026 07:00
- Source
- Stock Titan
Spyre Therapeutics (SYRE) CMO sells 8,333 shares, retains 313,334 options
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 03 Jun 2026 07:00
- Source
- Stock Titan
Spyre finishes arthritis trial enrollment, targets 2026 results in three diseases
- Tone
- Neutral 50/100
- Event
- Earnings
- Published
- 03 Jun 2026 07:00
- Source
- Stock Titan
There May Be Reason For Hope In Puma Biotechnology's (NASDAQ:PBYI) Disappointing Earnings
- Tone
- Negative 34/100
- Event
- Earnings
- Published
- 15 May 2026 07:00
- Source
- simplywall.st
Puma Biotechnology's (NASDAQ:PBYI) Conservative Accounting Might Explain Soft Earnings
- Tone
- Neutral 50/100
- Event
- Earnings
- Published
- 14 May 2026 07:00
- Source
- Market source
Puma Biotechnology, Inc. (NASDAQ:PBYI) Analysts Are Pretty Bullish On The Stock After Recent Results
- Tone
- Positive 66/100
- Event
- Earnings
- Published
- 11 May 2026 07:00
- Source
- simplywall.st
Earnings Update: Here's Why Analysts Just Lifted Their Puma Biotechnology, Inc. (NASDAQ:PBYI) Price Target To US$5.00
- Tone
- Neutral 50/100
- Event
- Earnings
- Published
- 11 May 2026 07:00
- Source
- Market source
Is Spyre Therapeutics (SYRE) One of the Small-Cap Stocks That Are On Fire Right Now?
- Tone
- Neutral 50/100
- Event
- Market update
- Published
- 30 Apr 2026 07:00
- Source
- Market source