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NASDAQEquity · Volume & Price

SLN

Silence Therapeutics PLC

US Healthcare Biotechnology

52-week price+51.7%
Latest week
9 Oct 2026
Chart Console
Weekly close
9.86 USD
Daily Price
Fair value
10.94 USD
Weekly Trend
Next-week expectancy
Undecided 46.08%
Weekly Report

Sharemaestro · Completed weekly data

Volume & Price

Where trading activity is concentrated, how it has changed, and what volume adds to the price move.

Open Volume & Price screener →

Latest week ·

Price is within the earlier activity area

The latest close is inside the activity area established before the last four weeks. 4 of those four closes were inside that area. Recent volume balance is negative; the estimated activity centre is higher.

52 weeks2025-10-17 to 2026-10-09Weekly volume estimate

The relationship beneath price · 2026-10-09

Mixed evidence

These diagnostics use fixed windows through the latest completed week. Chart period controls below change the activity study separately.

Four-week price move-24.3%8.5% over thirteen weeks
Latest relative volume2.45×2.46× recent four-week median
Closing pressure-49.0%Volume-weighted position within weekly ranges
Up-week volume share56.0%44.0% in declining weeks · last 13 weeks
At least twice normal volume

Price and pressure through time

Compare four-week returns with four-week closing pressure. Opposite signs reveal disagreement; agreement alone is not predictive.

View weekly evidence values
Week4-week returnPressureRelative volume
2025-10-1732.9%-11.3%1.92×
2025-10-2431.8%-7.0%2.96×
2025-10-3143.2%-8.7%1.71×
2025-11-0731.6%12.2%2.23×
2025-11-145.1%15.3%2.15×
2025-11-21-13.6%0.2%2.91×
2025-11-28-5.9%23.5%2.44×
2025-12-055.8%32.3%5.03×
2025-12-12-7.5%10.3%3.39×
2025-12-191.0%11.4%3.19×
2025-12-26-8.0%-4.5%1.82×
2026-01-02-11.6%-24.6%2.96×
2026-01-09-12.7%-40.4%2.85×
2026-01-16-20.9%-57.6%2.29×
2026-01-23-8.6%-41.3%1.72×
2026-01-30-21.6%-53.5%1.08×
2026-02-06-14.0%-27.3%1.18×
2026-02-13-11.7%-0.9%0.97×
2026-02-20-11.8%-7.0%0.63×
2026-02-2712.9%24.3%0.64×
2026-03-0631.2%42.4%1.81×
2026-03-1355.1%39.6%1.58×
2026-03-2023.4%-4.3%1.86×
2026-03-27-9.4%-30.3%2.00×
2026-04-03-4.7%-31.5%1.02×
2026-04-10-17.0%-24.5%1.56×
2026-04-1722.0%28.2%2.21×
2026-04-2456.2%33.8%1.84×
2026-05-0120.0%10.1%0.94×
2026-05-0821.6%0.9%0.85×
2026-05-15-19.0%-52.0%0.50×
2026-05-22-19.5%-42.5%0.84×
2026-05-29-3.2%-22.8%0.61×
2026-06-05-11.5%-34.2%0.67×
2026-06-129.7%0.7%0.98×
2026-06-1911.8%7.2%1.01×
2026-06-2647.0%44.6%3.92×
2026-07-0368.4%36.2%2.32×
2026-07-1035.9%9.5%1.70×
2026-07-1751.5%14.1%1.64×
2026-07-248.7%-21.2%1.63×
2026-07-311.0%-48.6%2.81×
2026-08-0731.5%-14.7%1.44×
2026-08-1430.7%-71.2%17.29×
2026-08-2120.4%-74.6%2.62×
2026-08-2827.9%-68.8%1.30×
2026-09-0422.1%-66.6%1.71×
2026-09-11-5.1%-37.3%1.58×
2026-09-18-8.1%-44.1%2.41×
2026-09-25-16.7%-55.7%1.62×
2026-10-02-27.1%-71.8%2.45×
2026-10-09-24.3%-49.0%2.45×

Does support survive a longer view?

Advancing-week volume share against price return and closing pressure.

4 weeks0%up-week volume-24.3%price return-49.0%pressure
13 weeks56%up-week volume8.5%price return-55.2%pressure
26 weeks61%up-week volume72.1%price return-40.6%pressure
52 weeks56%up-week volume97.2%price return-31.6%pressure

A high advancing-volume share alongside weak closing pressure can mean price rose between closes but finished low within its weekly ranges. The two measures answer different questions.

Effort and result

100% price efficiency

Four-week net price movement as a share of the total close-to-close path. Lower readings indicate more back-and-forth movement, regardless of volume.

Latest close: 51% of the way from the weekly low to high.

Volume-weighted return tilt

3.45 percentage points

The volume-weighted average weekly return minus the ordinary average over thirteen weeks. Positive means more volume coincided with stronger returns; negative means volume leaned toward weaker returns.

An association within this listing, not measured capital flow.

Constructive confirmation

29.0 / 100

Price direction15.0 / 30
Closing pressure0.0 / 30
Up-week volume14.0 / 25
Volume confirmation0.0 / 15

Fixed weights favour supported advances. A low score can still contain useful bearish or reversal research.

Test the volume contribution

Did heavier trading change what followed?

Compare high-volume and ordinary-volume weeks with the same price direction.

High volume is at least 1.5× its preceding 26-week median; ordinary volume is 0.75–1.25×. Returns start at that week’s close. Each group uses non-overlapping completed outcomes.

Starting observationAfterHigh-volume examplesMedian returnOrdinary examplesMedian returnDifference
Advancing weeks4 weeks35-4.8%192.5%-7.4 points
Advancing weeks13 weeks15-1.3%11-0.9%-0.4 points
Declining weeks4 weeks31-5.5%230.0%-5.5 points
Declining weeks13 weeks14-6.8%12-6.1%-0.8 points

At least eight completed examples in both groups are required. Groups may overlap each other, and differ in volatility, trend and market conditions; their difference is not a causal volume effect or a statistical claim of edge. Up to six years of available history; price returns exclude dividends, costs and execution. Fixed definitions have not been validated out of sample.

Inspect the dated observations

Advancing weeks · 4 weeks

Volume groupObservationOutcome dateReturn
High volume2021-04-302021-05-289.1%
High volume2021-05-282021-06-25-4.8%
High volume2021-07-302021-08-27-8.6%
High volume2021-08-272021-09-24-6.9%
High volume2021-09-242021-10-225.6%
High volume2021-11-052021-12-0312.4%
High volume2021-12-032021-12-31-7.1%
High volume2021-12-312022-01-28-18.4%
High volume2022-02-042022-03-04-19.6%
High volume2022-04-012022-04-29-37.6%
High volume2022-06-172022-07-1523.7%
High volume2022-08-262022-09-231.2%
High volume2022-10-072022-11-0429.8%
High volume2023-04-282023-05-26-14.6%
High volume2023-06-092023-07-07-3.2%
High volume2023-08-042023-09-0150.7%
High volume2023-11-032023-12-0147.3%
High volume2023-12-012023-12-2928.2%
High volume2024-01-052024-02-0224.3%
High volume2024-02-022024-03-0115.7%
High volume2024-03-012024-03-29-16.2%
High volume2024-04-122024-05-10-4.3%
High volume2024-07-122024-08-09-19.8%
High volume2024-10-042024-11-01-5.2%
High volume2024-11-292024-12-27-10.4%
High volume2024-12-272025-01-24-19.9%
High volume2025-10-172025-11-145.1%
High volume2025-11-142025-12-12-7.5%
High volume2025-12-192026-01-16-20.9%
High volume2026-01-232026-02-20-11.8%
High volume2026-03-062026-04-03-4.7%
High volume2026-04-172026-05-15-19.0%
High volume2026-06-262026-07-248.7%
High volume2026-07-242026-08-2120.4%
High volume2026-09-042026-10-02-27.1%
Ordinary volume2021-05-072021-06-042.5%
Ordinary volume2021-07-092021-08-06-4.7%
Ordinary volume2021-10-152021-11-124.0%
Ordinary volume2022-03-182022-04-151.4%
Ordinary volume2022-05-062022-06-03-24.7%
Ordinary volume2022-10-212022-11-1813.0%
Ordinary volume2023-06-232023-07-21-16.4%
Ordinary volume2023-12-292024-01-269.9%
Ordinary volume2024-04-192024-05-171.6%
Ordinary volume2024-06-212024-07-195.2%
Ordinary volume2024-08-302024-09-27-4.4%
Ordinary volume2024-10-252024-11-22-61.2%
Ordinary volume2025-01-032025-01-31-27.9%
Ordinary volume2025-03-072025-04-04-46.2%
Ordinary volume2025-04-182025-05-1639.2%
Ordinary volume2025-05-162025-06-1322.0%
Ordinary volume2026-04-032026-05-0120.0%
Ordinary volume2026-05-222026-06-1911.8%
Ordinary volume2026-06-192026-07-1751.5%

Advancing weeks · 13 weeks

Volume groupObservationOutcome dateReturn
High volume2021-04-302021-07-301.8%
High volume2021-07-302021-10-29-14.1%
High volume2021-11-052022-02-04-7.4%
High volume2022-02-042022-05-06-42.4%
High volume2022-06-172022-09-1629.1%
High volume2022-10-072023-01-0644.7%
High volume2023-04-282023-07-28-17.9%
High volume2023-08-042023-11-0363.1%
High volume2023-11-032024-02-02142.2%
High volume2024-02-022024-05-03-1.3%
High volume2024-07-122024-10-11-4.6%
High volume2024-11-292025-02-28-43.2%
High volume2025-10-172026-01-16-22.5%
High volume2026-01-232026-04-2435.8%
High volume2026-04-242026-07-2443.1%
Ordinary volume2021-05-072021-08-06-1.4%
Ordinary volume2021-10-152022-01-14-0.9%
Ordinary volume2022-03-182022-06-17-46.8%
Ordinary volume2022-10-212023-01-2017.3%
Ordinary volume2023-06-232023-09-2261.5%
Ordinary volume2023-12-292024-03-2924.4%
Ordinary volume2024-04-192024-07-19-8.7%
Ordinary volume2024-08-302024-11-29-58.5%
Ordinary volume2025-01-032025-04-04-64.7%
Ordinary volume2025-04-182025-07-1892.4%
Ordinary volume2026-04-032026-07-0374.9%

Declining weeks · 4 weeks

Volume groupObservationOutcome dateReturn
High volume2021-07-022021-07-302.4%
High volume2021-08-202021-09-17-4.8%
High volume2021-11-122021-12-108.9%
High volume2021-12-102022-01-07-5.3%
High volume2022-01-072022-02-04-9.4%
High volume2022-02-182022-03-18-11.2%
High volume2022-04-082022-05-06-30.3%
High volume2022-07-082022-08-05-12.1%
High volume2022-08-052022-09-026.0%
High volume2022-09-162022-10-14-7.7%
High volume2023-02-172023-03-17-31.6%
High volume2023-04-142023-05-12-7.1%
High volume2023-05-262023-06-2316.3%
High volume2023-09-012023-09-2915.5%
High volume2023-11-172023-12-1576.2%
High volume2024-01-122024-02-0924.5%
High volume2024-02-092024-03-0816.1%
High volume2024-03-082024-04-05-17.4%
High volume2024-06-282024-07-2610.5%
High volume2024-08-092024-09-0612.9%
High volume2024-11-152024-12-13-49.2%
High volume2024-12-132025-01-10-7.1%
High volume2025-01-172025-02-14-5.5%
High volume2025-02-142025-03-14-19.2%
High volume2025-04-112025-05-0944.0%
High volume2025-10-312025-11-28-5.9%
High volume2025-12-122026-01-09-12.7%
High volume2026-01-092026-02-06-14.0%
High volume2026-03-202026-04-1722.0%
High volume2026-07-102026-08-0731.5%
High volume2026-08-212026-09-18-8.1%
Ordinary volume2021-05-142021-06-1111.5%
Ordinary volume2021-10-292021-11-260.1%
Ordinary volume2022-04-152022-05-13-42.1%
Ordinary volume2022-05-132022-06-10-11.9%
Ordinary volume2022-06-102022-07-0830.4%
Ordinary volume2022-09-232022-10-214.9%
Ordinary volume2022-11-112022-12-0919.3%
Ordinary volume2022-12-232023-01-20-6.9%
Ordinary volume2023-02-032023-03-03-14.1%
Ordinary volume2023-03-312023-04-288.1%
Ordinary volume2023-05-052023-06-02-15.0%
Ordinary volume2023-06-022023-06-301.9%
Ordinary volume2023-06-302023-07-280.0%
Ordinary volume2023-09-082023-10-0611.2%
Ordinary volume2024-07-052024-08-023.5%
Ordinary volume2024-08-022024-08-301.3%
Ordinary volume2024-09-202024-10-18-1.5%
Ordinary volume2024-10-182024-11-15-29.4%
Ordinary volume2025-01-312025-02-28-15.6%
Ordinary volume2025-02-282025-03-28-23.6%
Ordinary volume2025-03-282025-04-25-2.3%
Ordinary volume2026-01-302026-02-2712.9%
Ordinary volume2026-05-012026-05-29-3.2%

Declining weeks · 13 weeks

Volume groupObservationOutcome dateReturn
High volume2021-07-022021-10-01-17.6%
High volume2021-11-122022-02-110.2%
High volume2022-02-182022-05-20-55.5%
High volume2022-07-082022-10-07-10.3%
High volume2023-02-172023-05-19-53.0%
High volume2023-05-262023-08-2561.0%
High volume2023-09-012023-12-0159.4%
High volume2024-01-122024-04-1225.3%
High volume2024-06-282024-09-27-4.0%
High volume2024-11-152025-02-14-61.9%
High volume2025-02-142025-05-16-9.7%
High volume2025-10-312026-01-30-32.7%
High volume2026-03-202026-06-1912.3%
High volume2026-07-102026-10-098.5%
Ordinary volume2021-05-142021-08-13-0.8%
Ordinary volume2021-10-292022-01-28-11.3%
Ordinary volume2022-04-152022-07-15-35.0%
Ordinary volume2022-09-232022-12-2332.2%
Ordinary volume2022-12-232023-03-24-35.1%
Ordinary volume2023-03-312023-06-30-11.3%
Ordinary volume2023-06-302023-09-2978.6%
Ordinary volume2024-07-052024-10-042.4%
Ordinary volume2024-10-182025-01-17-71.5%
Ordinary volume2025-01-312025-05-02-26.3%
Ordinary volume2026-01-302026-05-0147.9%
Ordinary volume2026-05-012026-07-3147.1%

Price, activity and volume balance

Where volume is concentrated

2026-10-09Close 9.86
Weekly priceEstimated volume at priceMost active priceEarlier activity areaEstimated volume balance

Move over the chart, tap a week, or use the arrow keys to inspect it. The profile estimates where volume sits within weekly price ranges. The lower chart accumulates volume weighted by where each week closed in its range; its starting point changes with the selected period. This is not trade-based CVD.

Most active price6.24
Earlier activity area4.19 – 14.23
Recent volume balance-49.0%
Recent weekly volume3.68×
View chart values
Completed weekly observations
Week endingCloseVolume
2025-10-176.50837799
2025-10-247.301291986
2025-10-317.16743883
2025-11-076.58974248
2025-11-146.83937577
2025-11-216.311270650
2025-11-286.741062547
2025-12-056.962191951
2025-12-126.321477850
2025-12-196.371392120
2025-12-266.20973248
2026-01-026.151582569
2026-01-095.521936508
2026-01-165.041809236
2026-01-235.671457971
2026-01-304.82975358
2026-02-064.751128797
2026-02-134.45941838
2026-02-205.00611310
2026-02-275.44623691
2026-03-066.231762894
2026-03-136.901543661
2026-03-206.171894382
2026-03-274.932194329
2026-04-035.941224987
2026-04-105.731940942
2026-04-177.532826365
2026-04-247.702473844
2026-05-017.131339047
2026-05-086.971208344
2026-05-156.10710379
2026-05-226.201199070
2026-05-296.90868357
2026-06-056.17948484
2026-06-126.691342057
2026-06-196.931347354
2026-06-2610.145250945
2026-07-0310.393123910
2026-07-109.092289100
2026-07-1710.502209644
2026-07-2411.022192655
2026-07-3110.493778578
2026-08-0711.952077306
2026-08-1413.7228580099
2026-08-2113.274792937
2026-08-2813.422493797
2026-09-0414.593430842
2026-09-1113.023366600
2026-09-1812.205295375
2026-09-2511.183569428
2026-10-0210.645503845
2026-10-099.865833140

Earlier and recent activity

What has changed?

The recent comparison uses the last four completed weeks.

Activity centre

Higher

The recent centre moved +8.92% against the earlier part of this period.

Price and volume

No clear disagreement

Price changed -24.27% over four weeks. Volume balance is -49.0% on a scale from −100% to +100%.

Volume and price movement

More volume, clear price movement

Recent median weekly volume is 3.68× the earlier median. This describes price response, not the identity of buyers or sellers.

Recent closes

4 of 4 closes inside

Price was inside the earlier area before these four weeks. The earlier boundaries stay fixed for this comparison.

Activity over time

Darker cells show more estimated volume at that price. Use the chart to see where activity has moved. For longer periods, a column combines several weeks.

Volume and price movement

Each dot is a week. Compare weekly volume with the move from open to close.

What to check next

Holding outside the area

Watch which boundary price moves beyond and whether later closes remain outside it.

Returning inside

Price is currently inside the earlier area. Repeated closes here would show that activity remains in the same price range.

Price and volume disagreeing

There is no clear disagreement at present. Check whether volume balance continues to support any further price move.

Same stock · Earlier observations

Previous examples

Descriptive history, not a forecast.

Comparisons use the same period length, position relative to the earlier activity area and direction of recent volume balance. Outcomes do not overlap for each following period. At least five examples are needed to show a matched median. The median is the middle result; the all-period median includes earlier periods regardless of their volume reading.

Subsequent price changes
AfterExamplesMedian changeSample
4 weeks244.0Available
13 weeks11-0.87Available

Returns are close-to-close price changes. Interim lows show the lowest price reached during the period. Dividends, fees and trade execution are not included. The available history contains up to six years of weekly observations.

Connected research

Test the same listing from another angle

How to read this report

Choose the period

The selected period sets the profile and volume balance starting point. “Start from a date” uses the first available week on or after that date. At least 13 consecutive weeks are required.

Compare earlier activity

The earlier activity area contains most of the estimated volume before the last four weeks. The activity centre is the average estimated price, weighted by volume. Compare subsequent closes with its boundaries, then read the volume balance alongside the price move.

Check the data

Volume is reported for the whole week. The distribution within the range and the direction of pressure are estimates. They cannot identify individual trades, investor holdings or institutional buying.

Reports use saved weekly data and refresh when those records change. Missing or invalid weeks restrict the available periods.

SLN · Volume & Price

Evidence context